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Irreversible and bivalent ligands for selected G-protein coupled receptors
thesisposted on 2002-01-01, 00:00 authored by Michael. McNaughton
Derivatives of pharmaceutical compounds that could potentially bind irreversibly to a hypertension controlling receptor were synthesised to provide tools for studying this receptor. Also compounds that simultaneously activate two cardiovascular receptors with opposing cellular mechanisms were synthesised. This resulted in a desired partial reduction in the activity of one receptor.