Molecular regulation of survivin targeted nano-therapy in advanced prostate cancer
thesis
posted on 2015-03-01, 00:00authored byJ Shankaranarayanan
The increasing complexities of prostate cancer disease progression necessitates more stable and less toxic therapeutic strategies. The current study demonstrated for the first time, the survivin targeted anti-cancer therapeutic activity of the bio-molecular drugs such as SurR9-C84A and bovine lactoferrin in inducing prostate cancer specific apoptosis. Moreover, improved therapeutic efficacy was conferred to these bio-molecules either by their encapsulation in stem cell targeted bio-compatible nanoparticles, or by the synthesis of protein-cytotoxic drug conjugates. This study also highlighted the role played by miRNAs in the regulation of iron metabolism and apoptosis, mediated by the selective activation of p53 and PTEN pathways.
History
Pagination
ix, 540 pages : illustrations, tables, graphs, some coloured