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Quality control mechanisms regulating the copper-transporting ATPases ATP7A and ATP7B

thesis
posted on 2012-07-01, 00:00 authored by S Materia
This project provides compelling evidence that the clusterin, COMMD1 and ApoE proteins function in the quality control of the essential copper-transport proteins ATP7A and ATP7B. This knowledge is significant because variations in the clusterin, COMMD1 or ApoE genes may explain the variability of patient symptoms in the copper-transport disorders, Menkes and Wilson diseases.

History

Pagination

xix, 282 pages : diagrams, tables, some coloured

Material type

thesis

Resource type

thesis

Language

eng

Degree type

Research doctorate

Degree name

Ph.D.

Copyright notice

The author

Editor/Contributor(s)

F Mercer Julian F.B., S La Fontaine, M Cater

Faculty

Faculty of Science and Technology

School

School of Life and Environmental Sciences

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    Theses

    Categories

    Keywords

    copper-transport proteinscopper-transport disordersATP7AATP7BMenkes diseaseWilson diseaseBiochemistry and Cell Biology not elsewhere classifiedProteomics and Intermolecular Interactions (excl. Medical Proteomics)

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    All Rights Reserved

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