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Quality control mechanisms regulating the copper-transporting ATPases ATP7A and ATP7B
thesisposted on 2012-07-01, 00:00 authored by S Materia
This project provides compelling evidence that the clusterin, COMMD1 and ApoE proteins function in the quality control of the essential copper-transport proteins ATP7A and ATP7B. This knowledge is significant because variations in the clusterin, COMMD1 or ApoE genes may explain the variability of patient symptoms in the copper-transport disorders, Menkes and Wilson diseases.