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Recombinant influenza viruses as a vaccine vector for HIV

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thesis
posted on 2015-03-01, 00:00 authored by Mohammed Jasim Mohammed Shallal
Live recombinant influenza viruses were successfully used as HIV vaccine vectors in a mouse model. Following intranasal prime-boost vaccination, HIV-specific CD8+ T cell responses were detected in the spleen, broncho-alveolar lavage, mediastinal and inguinal lymph nodes. HIV+α4β7+ CD8+ T cells contributed to protection in pseudo-challenge experiments using recombinant vaccinia virus expressing HIV antigens. This research highlights the importance of mucosal CD8+ T cells in viral immunity and emphasizes the need for additional studies to provide key insights to underpin future vaccine development.

History

Pagination

xvii, 217 pages : illustrations, tables, graphs

Open access

  • Yes

Material type

thesis

Resource type

thesis

Language

eng

Degree type

Research doctorate

Degree name

PhD

Copyright notice

The Author. All Rights Reserved

Editor/Contributor(s)

C Ward Alister C., S John Stambas, A Bean

Faculty

Faculty of Health

School

School of Medicine