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Reporter-gene assays for monoclonal antibodies

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thesis
posted on 2019-02-01, 00:00 authored by Kriti Bimalendu Ray
There is a need to develop rapid, sensitive and cost-effective potency assays to test monoclonal antibodies (MAbs). This study investigated the use of reporter-gene assays (RGAs) as potency assays, to test anti-IL-6/IL6R and anti-EGF/EGFR MAbs, using destabilized EGFP and luciferase as reporter genes.

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Pagination

366 p.

Open access

  • Yes

Material type

thesis

Resource type

thesis

Language

eng

Degree type

Research doctorate

Degree name

Ph.D.

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The author

Editor/Contributor(s)

B Ujvari, J Donald

Faculty

Faculty of Science

School

Engineering and Built Environment

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    Theses

    Categories

    Keywords

    untaggedSignal TransductionSynthetic BiologyCancer Therapy (excl. Chemotherapy and Radiation Therapy)

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    All Rights Reserved

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