addinsall-regulationofskeletal-2018.pdf (8.45 MB)
The regulation of skeletal muscle contractile function by Selenoprotein S.
thesisposted on 2018-10-01, 00:00 authored by A Addinsall
These doctoral studies investigated the novel role of an endoplasmic reticulum-resident antioxidant selenoprotein; Selenoprotein S (SEPS1) in skeletal muscle metabolism, cellular stress and contraction. The research outcomes demonstrate that SEPS1 possesses a fast fibre type-specific effect within skeletal muscle, where reduction of SEPS1 impairs cellular stress regulation and muscle performance.