Strategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templates
Pfeffer, Frederick and Russell, Richard. A. 2003, Strategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templates, Organic and biomolecular chemistry, vol. 1, pp. 1845-1851, doi: 10.1039/b301980b.
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Title
Strategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templates
A versatile synthesis of amino acid and peptide functionalised [n]polynorbornane scaffolds is described. The frameworks are constructed using the stereoselective and regioselective cycloaddition of suitably functionalised chiral cyclobutene epoxides with similar norbornenes. The strategies employed allow a range of topologies to be accessed and a number of regioselectively addressable linkage points to be accommodated.
Notes
First published as an Advance Article on the web 25th April 2003
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