Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein Gao, Yuan, Feng, Helen C., Walder, Ken, Bolton, Kristy, Sunderland, Terry, Bishara, Natalie, Quick, Melissa, Kantham, Lakshmi and Collier, Greg R. 2004, Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein, FEBS letters, vol. 563, no. 1-3, pp. 185-190, doi: 10.1016/S0014-5793(04)00296-0. Attached Files Name Description MIMEType Size Downloads walder-regulationsof-2004.pdf Published version application/pdf 762.13KB 208 Title Regulation of selenoprotein SelS by glucose deprivation and endoplasmic reticulum stress - SelS is a novel glucose-regulated protein Author(s) Gao, Yuan Feng, Helen C. Walder, Ken orcid.org/0000-0002-6758-4763 Bolton, Kristy orcid.org/0000-0001-6721-4503 Sunderland, Terry Bishara, Natalie Quick, Melissa Kantham, Lakshmi Collier, Greg R. Journal name FEBS letters Volume number 563 Issue number 1-3 Start page 185 End page 190 Publisher Elsevier BV Place of publication Amsterdam, Netherlands Publication date 2004-04-09 ISSN 0014-5793 1873-3468 Keyword(s) selenoprotein glucose-regulated protein glucose deprivation endoplasmic reticulum stress gene expression Summary SelS is a newly identified selenoprotein and its gene expression is up-regulated in the liver of Psammomys obesus after fasting. We have examined whether SelS is regulated by glucose deprivation and endoplasmic reticulum (ER) stress in HepG2 cells. Glucose deprivation and the ER stress inducers tunicamycin and thapsigargin increased SelS gene expression and protein content several-fold in parallel with glucose-regulated protein 78. The overexpression of SelS increased Min6 cell resistance to oxidative stress-induced toxicity. These results indicate that SelS is a novel member of the glucose-regulated protein family and its function is related to the regulation of cellular redox balance. Notes Available online 19 March 2004. Language eng DOI 10.1016/S0014-5793(04)00296-0 Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2004, Elsevier Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30002457 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Connected to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Tue, 27 Jan 2009, 11:28:28 EST Mon, 19 Apr 2010, 14:50:36 EST Fri, 23 Apr 2010, 11:04:11 EST Mon, 15 Apr 2013, 14:57:54 EST Fri, 13 Jun 2014, 22:18:42 EST Fri, 17 Oct 2014, 08:14:38 EST Tue, 06 Sep 2016, 08:54:39 EST Mon, 04 Dec 2017, 13:33:16 EST Fri, 07 Sep 2018, 13:10:20 EST Filtered Full Citation counts:   Cited 125 times in TR Web of Science Cited 130 times in Scopus Search Google Scholar Access Statistics: 1066 Abstract Views, 208 File Downloads  -  Detailed Statistics Created: Mon, 07 Jul 2008, 08:25:15 EST