Comparative aspects of natriuretic peptide physiology in non-mammalian vertebrates: a review Toop, Tes and Donald, John 2004, Comparative aspects of natriuretic peptide physiology in non-mammalian vertebrates: a review, Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, vol. 174, no. 3, pp. 189-204, doi: 10.1007/s00360-003-0408-y. Attached Files Name Description MIMEType Size Downloads Title Comparative aspects of natriuretic peptide physiology in non-mammalian vertebrates: a review Author(s) Toop, Tes Donald, John orcid.org/0000-0001-5930-2642 Journal name Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Volume number 174 Issue number 3 Start page 189 End page 204 Publisher Spring-Verlag Place of publication Berlin, Germany Publication date 2004-04 ISSN 0174-1578 1432-136X Keyword(s) natriuretic peptide natriuretic peptide receptor osmoregulation cardiovascular regulation kidney Summary The natriuretic peptide system is a complex family of peptides and receptors that is primarily linked to the maintenance of osmotic and cardiovascular homeostasis. A natriuretic peptide system is present in each vertebrate class but there are varying degrees of complexity in the system. In agnathans and chondrichthyians, only one natriuretic peptide has been identified, while new data has revealed that multiple types of natriuretic peptides are present in bony fish. However, it seems in tetrapods that there has been a reduction in the number of natriuretic peptide genes, such that only three natriuretic peptides are present in mammals. The peptides act via a family of guanylyl cyclase receptors to generate the second messenger cGMP, which  mediates a range of physiological effects at key targets such as the gills, kidney and the cardiovascular system. This review summarises the current knowledge of the natriuretic peptide system in non-mammalian vertebrates and discusses the physiological actions of the peptides. Language eng DOI 10.1007/s00360-003-0408-y Field of Research 060603 Animal Physiology - Systems HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2004, Springer-Verlag Persistent URL http://hdl.handle.net/10536/DRO/DU:30002713 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Biological and Chemical Sciences Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 10 Feb 2009, 10:49:19 EST Wed, 15 Jul 2009, 10:13:38 EST Fri, 13 Jun 2014, 22:40:57 EST Filtered Full Citation counts:   Cited 71 times in TR Web of Science Cited 77 times in Scopus Search Google Scholar Access Statistics: 992 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 07 Jul 2008, 08:32:25 EST