Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance

Oldroyd, John Charles, Unwin, Nigel C., White, Martin, Mathers, John C. and Alberti, K. G. M. M. 2006, Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance, Diabetes research and clinical practice, vol. 72, no. 2, pp. 117-127, doi: 10.1016/j.diabres.2005.09.018.

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Title Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance
Author(s) Oldroyd, John Charles
Unwin, Nigel C.
White, Martin
Mathers, John C.
Alberti, K. G. M. M.
Journal name Diabetes research and clinical practice
Volume number 72
Issue number 2
Start page 117
End page 127
Publisher Elsvier Ireland Ltd
Place of publication Shannon, Ireland
Publication date 2006-05
ISSN 0168-8227
Keyword(s) impaired glucose tolerance
physical activity
type 2 diabetes
coronary heart disease
Summary Aim

To evaluate the effectiveness of lifestyle interventions in people with impaired glucose tolerance (IGT).

Participants with IGT (n = 78), diagnosed on two consecutive oral glucose tolerance tests (OGTTs), were randomly assigned to a 2-year lifestyle intervention or to a control group. Main outcome measures were changes from baseline in: nutrient intake; physical activity; anthropometry, glucose tolerance and insulin sensitivity. Measurements were repeated at 6, 12 and 24 months follow-up.

After 24 months follow-up, there was a significant fall in total fat consumption (difference in change between groups (Δ intervention − Δ control) = −17.9, 95% confidence interval (CI) −33.6 to −2.1 g/day) as a result of the intervention. Body mass was significantly lower in the intervention group compared with controls after 6 months (−1.6, 95% CI −2.9 to −0.4 kg) and 24 months (−3.3, 95% CI −5.7 to −0.89 kg). Whole body insulin sensitivity, assessed by the short insulin tolerance test (ITT), improved after 12 months in the intervention group (0.52, 95% CI 0.15–0.89%/min).

These findings complement the findings of the Finnish Diabetes Prevention Study and the American Diabetes Prevention Study, both of which tested intensive interventions, by showing that pragmatic lifestyle interventions result in improvements in obesity and whole body insulin sensitivity in individuals with IGT, without change in other cardiovascular risk factors.
Notes Available online 16 November 2005.
Language eng
DOI 10.1016/j.diabres.2005.09.018
Field of Research 110306 Endocrinology
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30004130

Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
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