Emerging host cell targets for hepatitis C therapy

He, Yupeng, Duan, Wei and Tan, Seng-Lai 2007, Emerging host cell targets for hepatitis C therapy, Drug discovery today, vol. 12, no. 5, pp. 209-217, doi: 10.1016/j.drudis.2007.01.009.

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Title Emerging host cell targets for hepatitis C therapy
Author(s) He, Yupeng
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Tan, Seng-Lai
Journal name Drug discovery today
Volume number 12
Issue number 5
Start page 209
End page 217
Publisher Elsevier Ltd.
Place of publication Barking, England
Publication date 2007-03
ISSN 1359-6446
Summary Chronic hepatitis C virus (HCV) infection is a major burden on humanity. The current HCV therapy has limited efficacy, and there is pressing need for new and more effective therapies. Host cell factors that are required for HCV infection, replication and/or pathogenesis represent potential therapeutic targets. Of particular interest are cellular receptors that mediate HCV entry, factors that facilitate HCV replication and assembly, and intracellular pathways involving lipid biosynthesis, oxidative stress and innate immune response. A crucial challenge now is to manipulate such cellular targets pharmacologically for chronic HCV treatment, without being limited by side effects.
Language eng
DOI 10.1016/j.drudis.2007.01.009
Field of Research 110706 Immunogenetics (incl Genetic Immunology)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Elsevier Ltd.
Persistent URL http://hdl.handle.net/10536/DRO/DU:30007091

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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