Rapid determination of papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection Costin, Jason, Lewis, Simon, Purcell, Stuart D., Waddell, Lucy, Francis, Paul and Barnett, Neil 2007, Rapid determination of papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection, Analytica chimica acta, vol. 597, no. 1, pp. 19-23, doi: 10.1016/j.aca.2007.06.044. Attached Files Name Description MIMEType Size Downloads Title Rapid determination of papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection Formatted title Rapid determination of Papaver somniferum alkaloids in process streams using monolithic column high-performance liquid chromatography with chemiluminescence detection Author(s) Costin, Jason Lewis, Simon Purcell, Stuart D. Waddell, Lucy Francis, Paul orcid.org/0000-0003-4165-6922 Barnett, Neil Journal name Analytica chimica acta Volume number 597 Issue number 1 Start page 19 End page 23 Publisher Elsevier BV Place of publication Amsterdam, Netherlands Publication date 2007-07-30 ISSN 0003-2670 1873-4324 Keyword(s) monolithic column alkaloids chemiluminescence Summary We have combined high-performance liquid chromatography (HPLC) separations using a monolithic column with acidic potassium permanganate and tris(2,2′-bipyridyl)ruthenium(II) chemiluminescence detection in a rapid and highly sensitive method to monitor the process of extracting opiate alkaloids from Papaver somniferum. Due to the high flow rates allowed with the monolithic column and the inherent selectivity of the chemiluminescence reactions, the four predominant alkaloids – morphine, codeine, oripavine and thebaine – were determined in less than 2 min. The results obtained with numerous process samples compared favourable with those of the standard HPLC methodology. Limits of detection were 1 × 10−10 M, 5 × 10−10 M, 5 × 10−10 M and 1 × 10−9 M, for morphine, codeine, oripavine and thebaine, respectively. Notes Available online 27 June 2007. Language eng DOI 10.1016/j.aca.2007.06.044 Field of Research 030108 Separation Science Socio Economic Objective 970103 Expanding Knowledge in the Chemical Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2007, Elsevier B.V. Persistent URL http://hdl.handle.net/10536/DRO/DU:30007489 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 03 Nov 2008, 11:02:53 EST Mon, 08 Jun 2009, 14:42:13 EST Wed, 02 Oct 2013, 08:51:22 EST Wed, 02 Oct 2013, 08:52:38 EST Mon, 16 Jun 2014, 08:49:14 EST Fri, 22 Aug 2014, 15:40:42 EST Wed, 27 Aug 2014, 21:35:13 EST Filtered Full Citation counts:   Cited 41 times in TR Web of Science Cited 44 times in Scopus Search Google Scholar Access Statistics: 1146 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 29 Sep 2008, 08:52:42 EST