Determination of opiate alkaloids in process liquors using capillary electrophoresis Hindson, Benjamin, Francis, Paul, Purcell, Stuart D. and Barnett, Neil 2007, Determination of opiate alkaloids in process liquors using capillary electrophoresis, Journal of pharmaceutical and biomedical analysis, vol. 43, no. 3, pp. 1164-1168, doi: 10.1016/j.jpba.2006.09.040. Attached Files Name Description MIMEType Size Downloads Title Determination of opiate alkaloids in process liquors using capillary electrophoresis Author(s) Hindson, Benjamin Francis, Paul orcid.org/0000-0003-4165-6922 Purcell, Stuart D. Barnett, Neil Journal name Journal of pharmaceutical and biomedical analysis Volume number 43 Issue number 3 Start page 1164 End page 1168 Publisher Elsevier Place of publication New York, NY. Publication date 2007-02-19 ISSN 0731-7085 1873-264X Keyword(s) papaver somniferum alkaloids morphine codeine cyclodextrins Summary This paper describes the determination of opiate alkaloids (morphine, codeine, oripavine and thebaine) in industrial process liquors using capillary zone electrophoresis with UV-absorption detection at 214 nm. A study of cyclodextrin type and concentration revealed that the addition of 30 mM hydroxypropyl-β-cyclodextrin to the electrolyte solution (100 mM Tris adjusted to pH 2.8) was suitable to resolve the four analytes of interest. Typical analysis time was 12 min and the limit of detection for each alkaloid was 2.5 × 10−6 M. The results for the proposed methodology were in good agreement with those of a conventional HPLC procedure. Under the same conditions, short-end injection was used to reduce the effective separation length from 41.5 to 8.5 cm, which allowed the determination of morphine and thebaine in process liquors within 2.5 min. Language eng DOI 10.1016/j.jpba.2006.09.040 Field of Research 030108 Separation Science HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2006, Elsevier B.V. Persistent URL http://hdl.handle.net/10536/DRO/DU:30007497 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 03 Nov 2008, 09:48:32 EST Wed, 06 May 2009, 11:25:01 EST Mon, 16 Jun 2014, 08:49:40 EST Fri, 22 Aug 2014, 14:15:51 EST Wed, 27 Aug 2014, 21:35:32 EST Filtered Full Citation counts:   Cited 25 times in TR Web of Science Cited 27 times in Scopus Search Google Scholar Access Statistics: 1160 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 29 Sep 2008, 08:52:48 EST