Conversion of urea to hydrazine: Hofmann reaction or Favorskii analogue? Exploring reaction mechanism through isotopic labeling studies Francis, Paul and Lim, Kieran 2007, Conversion of urea to hydrazine: Hofmann reaction or Favorskii analogue? Exploring reaction mechanism through isotopic labeling studies, Chemical educator, vol. 12, no. 5, pp. 307-313, doi: 10.1333/s00897072074a. Attached Files Name Description MIMEType Size Downloads Title Conversion of urea to hydrazine: Hofmann reaction or Favorskii analogue? Exploring reaction mechanism through isotopic labeling studies Author(s) Francis, Paul orcid.org/0000-0003-4165-6922 Lim, Kieran orcid.org/0000-0001-5355-8030 Journal name Chemical educator Volume number 12 Issue number 5 Start page 307 End page 313 Publisher Boise State University Place of publication Boise, Ind. Publication date 2007-10 ISSN 1430-4171 Keyword(s) in the classroom organic chemistry physical chemistry isotopes kinetics mechanisms of reactions Summary The power of isotopic substitution for the elucidation of a reaction mechanism is illustrated with reactions named after Hofmann and Favorskii. These reactions have important roles in synthetic chemistry; therefore, a wide range of experiments involving isotopic labeling or kinetic isotope effects were employed to establish their mechanistic pathways. The concepts introduced by these investigations are drawn together with an isotopic labeling study of the oxidation of urea with hypohalites. The two mechanisms proposed for this reaction have been described as a Hofmann rearrangement and a nitrogen analogue of the Favorskii rearrangement. Language eng DOI 10.1333/s00897072074a Field of Research 030601 Catalysis and Mechanisms of Reactions Socio Economic Objective 970103 HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2007, Boise State University Persistent URL http://hdl.handle.net/10536/DRO/DU:30007500 Document type: Journal Article Collections: Faculty of Arts and Education Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Higher Education Research Group Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 02 Feb 2009, 14:14:36 EST Wed, 06 May 2009, 13:57:44 EST Mon, 23 Jul 2012, 08:57:22 EST Fri, 28 Sep 2012, 10:35:32 EST Wed, 27 Aug 2014, 21:35:43 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 2663 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 29 Sep 2008, 08:52:50 EST