The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease

Ward, Alister 2007, The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease, Frontiers in bioscience, vol. 12, no. 2, pp. 608-618, doi: 10.2741/2086.

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Title The role of the granulocyte colony-stimulating factor receptor (G-CSF-R) in disease
Author(s) Ward, AlisterORCID iD for Ward, Alister
Journal name Frontiers in bioscience
Volume number 12
Issue number 2
Start page 608
End page 618
Publisher Frontiers in Bioscience
Place of publication Tampa, Florida
Publication date 2007-01
ISSN 1093-9946
Summary Granulocyte colony-stimulating factor (G-CSF) is a key regulator of granulopoiesis via stimulation of a specific cell-surface receptor, the G-CSF-R, found on hematopoietic progenitor cells as well as neutrophilic granulocytes. It is perhaps not surprising, therefore, that mutations of the G-CSF-R has been implicated in several clinical settings that affect granulocytic differentiation, particularly severe congenital neutropenia, myelodysplastic syndrome and acute myeloid leukemia. However, other studies suggest that signalling via the G-CSF-R is also involved in a range of other malignancies. This review focuses on the molecular mechanisms through which the G-CSF-R contributes to disease.
Notes TABLE OF CONTENTS 1. Abstract 2. Introduction 2.1. G-CSF and its receptor 2.2. Neutropenia and other relevant disorders 2.3. G-CSF therapy 3. Direct role of G-CSF-R mutations in myeloid disorders 3.1. "Hyperresponsive" intracellular truncations 3.1.1. Clinical details 3.1.2. Mouse models 3.1.3. Molecular mechanisms 3.2. "Crippling" extracellular mutants 3.3. "Activating" transmembrane mutants 3.4. Other mutants 4. Indirect involvement of the G-CSF-R in disease 5. Conclusions 6. Acknowledgments 7. References (
Language eng
DOI 10.2741/2086
Field of Research 110399 Clinical Sciences not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Frontiers in BioScience
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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