Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from α-linolenic acid in healthy human volunteers Attar-Bashi, N. M., Weisinger, R. S., Begg, D. P., Sinclair, Andrew and Li, D. 2007, Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from α-linolenic acid in healthy human volunteers, Prostaglandins, leukotrienes and essential fatty acids, vol. 76, no. 3, pp. 121-130. Attached Files Name Description MIMEType Size Downloads Title Failure of conjugated linoleic acid supplementation to enhance biosynthesis of docosahexaenoic acid from α-linolenic acid in healthy human volunteers Author(s) Attar-Bashi, N. M. Weisinger, R. S. Begg, D. P. Sinclair, Andrew Li, D. Journal name Prostaglandins, leukotrienes and essential fatty acids Volume number 76 Issue number 3 Start page 121 End page 130 Publisher Churchill Livingstone Place of publication Edinburgh, Scotland Publication date 2007-03 ISSN 0952-3278 1532-2823 Summary A rate-limiting step in docosahexaenoic acid (DHA) formation from α-linolenic acid (ALA) involves peroxisomal oxidation of 24:6n-3 to DHA. The aim of the study was to determine whether conjugated linoleic acid (CLA) would enhance conversion of ALA to DHA in humans on an ALA-supplemented diet. The subjects (n=8 per group) received daily supplementation of ALA (11g) and either CLA (3.2g) or placebo for 8 weeks. At baseline, 4 and 8 weeks, blood was collected for plasma fatty acid analysis and a number of physiological measures were examined. The ALA-supplemented diet increased plasma levels of ALA and eicosapentaenoic acid (EPA). The addition of CLA to the ALA diet resulted in increased plasma levels of CLA, as well as ALA and EPA. Plasma level of DHA was not increased with either the ALA alone or ALA plus CLA supplementation. The results demonstrated that CLA was not effective in enhancing DHA levels in plasma in healthy volunteers. Notes Available online 1 February 2007. Language eng Field of Research 110104 Medical Biochemistry: Lipids HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2006, Elsevier Ltd Persistent URL http://hdl.handle.net/10536/DRO/DU:30007683 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connected to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 05 Feb 2009, 14:32:06 EST Mon, 07 Sep 2009, 15:42:57 EST Mon, 19 Apr 2010, 11:16:58 EST Mon, 11 Apr 2011, 16:33:30 EST Mon, 16 Jun 2014, 09:01:07 EST Filtered Full Citation counts:   Cited 22 times in TR Web of Science Cited 24 times in Scopus Search Google Scholar Access Statistics: 955 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 29 Sep 2008, 08:54:56 EST