Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing Aqueous outflow Nguyen, Christine, Bui, Bang, Sinclair, Andrew and Vingrys, Algis 2007, Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing Aqueous outflow, Investigative ophthalmology and visual science (IOVS), vol. 48, no. 2, pp. 756-762, doi: 10.1167/iovs.06-0585. Attached Files Name Description MIMEType Size Downloads Title Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing Aqueous outflow Author(s) Nguyen, Christine Bui, Bang Sinclair, Andrew Vingrys, Algis Journal name Investigative ophthalmology and visual science (IOVS) Volume number 48 Issue number 2 Start page 756 End page 762 Publisher Association for Research in Vision and Ophthalmology Place of publication St. Louis, Mo. Publication date 2007 ISSN 0146-0404 1552-5783 Summary Purpose: To determine whether there is an association between dietary omega-3 (ω-3) fatty acid intake, age, and intraocular pressure (IOP) caused by altered aqueous outflow. Methods: Sprague–Dawley rats were fed either ω-3–sufficient (ω-3+) or ω-3–deficient (ω-3–) diets from conception. The diets had 7% lipid content. The ω-3+ diet contained safflower, flaxseed, and tuna oils (5.5:1.0:0.5), and the ω-3– diet contained safflower oil only. Intraocular pressure was measured at 5 to 40 weeks of age under light anesthesia (ω-3+, n = 39; ω-3–, n = 48). Aqueous outflow was determined at 45 weeks in a subgroup of animals (ω-3+, n = 15;ω-3–, n = 22) using pulsed infusion. Ciliary body tissues (n = 6 per group) were assayed for fatty acid content by thin-layer and gas-liquid chromatography in both diet groups. Results: Animals raised on ω-3+ diets had a 13% decrease in IOP at 40 weeks of age (13.48 ± 0.32 mm Hg vs. 15.46 ± 0.29 mm Hg; P < 0.01). When considered as a change in IOP relative to 5 weeks of age, the ω-3+ group showed a 23% decrease (P < 0.001). This lower IOP in the ω-3+ diet group was associated with a significant increase (+56%; P < 0.001) in outflow facility and a decrease in ocular rigidity (–59%; P < 0.001). The ω-3+ group showed a 3.3 times increase in ciliary body docosahexaenoic acid (P < 0.001). Conclusions: Increasing dietary ω-3 reduces IOP with age because of increased outflow facility, likely resulting from an increase in docosanoids. This indicates that dietary manipulation may provide a modifiable factor for IOP regulation. However, further studies are needed to consider whether this can modify the risk for glaucoma and can play a role in treatment of the disease. Language eng DOI 10.1167/iovs.06-0585 Field of Research 111399 Ophthalmology and Optometry not elsewhere classified HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2007, Association for Research in Vision and Ophthalmology Persistent URL http://hdl.handle.net/10536/DRO/DU:30007685 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 14 Jan 2009, 13:32:51 EST Mon, 07 Sep 2009, 15:57:07 EST Thu, 08 Apr 2010, 11:59:23 EST Mon, 16 Jun 2014, 09:01:18 EST Wed, 06 Nov 2019, 20:39:20 EST Thu, 18 Feb 2021, 20:36:58 EST Filtered Full Citation counts:   Cited 48 times in TR Web of Science Cited 54 times in Scopus Search Google Scholar Access Statistics: 1060 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 29 Sep 2008, 08:54:57 EST