Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing Aqueous outflow

Nguyen, Christine, Bui, Bang, Sinclair, Andrew and Vingrys, Algis 2007, Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing Aqueous outflow, Investigative ophthalmology and visual science (IOVS), vol. 48, no. 2, pp. 756-762, doi: 10.1167/iovs.06-0585.

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Title Dietary omega 3 fatty acids decrease intraocular pressure with age by increasing Aqueous outflow
Author(s) Nguyen, Christine
Bui, Bang
Sinclair, Andrew
Vingrys, Algis
Journal name Investigative ophthalmology and visual science (IOVS)
Volume number 48
Issue number 2
Start page 756
End page 762
Publisher Association for Research in Vision and Ophthalmology
Place of publication St. Louis, Mo.
Publication date 2007
ISSN 0146-0404
Summary Purpose: To determine whether there is an association between dietary omega-3 (ω-3) fatty acid intake, age, and intraocular pressure (IOP) caused by altered aqueous outflow. Methods: Sprague–Dawley rats were fed either ω-3–sufficient (ω-3+) or ω-3–deficient (ω-3) diets from conception. The diets had 7% lipid content. The ω-3+ diet contained safflower, flaxseed, and tuna oils (5.5:1.0:0.5), and the ω-3 diet contained safflower oil only. Intraocular pressure was measured at 5 to 40 weeks of age under light anesthesia (ω-3+, n = 39; ω-3, n = 48). Aqueous outflow was determined at 45 weeks in a subgroup of animals (ω-3+, n = 15;ω-3, n = 22) using pulsed infusion. Ciliary body tissues (n = 6 per group) were assayed for fatty acid content by thin-layer and gas-liquid chromatography in both diet groups. Results: Animals raised on ω-3+ diets had a 13% decrease in IOP at 40 weeks of age (13.48 ± 0.32 mm Hg vs. 15.46 ± 0.29 mm Hg; P < 0.01). When considered as a change in IOP relative to 5 weeks of age, the ω-3+ group showed a 23% decrease (P < 0.001). This lower IOP in the ω-3+ diet group was associated with a significant increase (+56%; P < 0.001) in outflow facility and a decrease in ocular rigidity (–59%; P < 0.001). The ω-3+ group showed a 3.3 times increase in ciliary body docosahexaenoic acid (P < 0.001). Conclusions: Increasing dietary ω-3 reduces IOP with age because of increased outflow facility, likely resulting from an increase in docosanoids. This indicates that dietary manipulation may provide a modifiable factor for IOP regulation. However, further studies are needed to consider whether this can modify the risk for glaucoma and can play a role in treatment of the disease.
Language eng
DOI 10.1167/iovs.06-0585
Field of Research 111399 Ophthalmology and Optometry not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2007, Association for Research in Vision and Ophthalmology
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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