The influence of allopurinol on urinary purine loss after repeated sprint exercise in man

Stathis, Christos G., Carey, Michael F. and Snow, Rod 2005, The influence of allopurinol on urinary purine loss after repeated sprint exercise in man, Metabolism, clinical and experimental, vol. 54, no. 10, pp. 1269-1275, doi: 10.1016/j.metabol.2005.02.004.

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Title The influence of allopurinol on urinary purine loss after repeated sprint exercise in man
Author(s) Stathis, Christos G.
Carey, Michael F.
Snow, RodORCID iD for Snow, Rod
Journal name Metabolism, clinical and experimental
Volume number 54
Issue number 10
Start page 1269
End page 1275
Publisher W.B. Saunders Co.
Place of publication Philadelphia, Pa.
Publication date 2005-10
ISSN 0026-0495
Summary The influence of allopurinol on urinary purine loss was examined in 7 active male subjects (age 24.9 ± 3.0 years, weight 82.8 ± 8.3 kg, V˙o2peak 48.1 ± 6.9 mL · kg−1 · min−1). These subjects performed, in random order, a trial with 5 days of prior ingestion of a placebo or allopurinol. Each trial consisted of eight 10-second sprints on an air-braked cycle ergometer and was separated by at least a week. A rest period of 50 seconds separated each repeated sprint. Forearm venous plasma inosine, hypoxanthine (Hx) and uric acid concentrations were measured at rest and during 120 minutes of recovery from exercise. Urinary inosine, Hx, xanthine, and uric acid excretion were also measured before and for 24 hours after exercise. During the first 120 minutes of recovery, plasma Hx concentrations, as well as the urinary Hx and xanthine excretion rates, were higher (P < .05) with allopurinol compared with the placebo trial. In contrast, plasma uric acid concentration and urinary uric acid excretion rates were lower (P < .05) with allopurinol. The total urinary excretion of purines (inosine + Hx + xanthine + uric acid) above basal levels was higher in the allopurinol trial compared with placebo. These results indicate that the total urinary purine excretion after intermittent sprint exercise was enhanced with allopurinol treatment. Furthermore, the composition of urinary purines was markedly affected by this drug.
Notes Available online 9 September 2005.
Language eng
DOI 10.1016/j.metabol.2005.02.004
Field of Research 110602 Exercise Physiology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2005, Elsevier Inc.
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