Relationship between platelet phospholipid FA and mean platelet volume in healthy men

Li, Duo, Turner, Alan and Sinclair, Andrew 2002, Relationship between platelet phospholipid FA and mean platelet volume in healthy men, Lipids, vol. 37, no. 9, pp. 901-906, doi: 10.1007/s11745-002-0977-0.

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Title Relationship between platelet phospholipid FA and mean platelet volume in healthy men
Author(s) Li, Duo
Turner, Alan
Sinclair, Andrew
Journal name Lipids
Volume number 37
Issue number 9
Start page 901
End page 906
Publisher Springer
Place of publication Berlin , Germany
Publication date 2002
ISSN 0024-4201
Summary Increased mean platelet volume (MPV) has been suggested as an independent risk factor for acute myocardial infarction and the increased reactivity of large platelets. The aim of this study was to investigate the correlation between platelet phospholipid (PL) PUFA composition and MPV in 139 free-living healthy men ages 20-55 yr (vegans, n = 18; ovolacto vegetarians, n = 43; moderate meat-eaters, n = 60; and high meateaters, n = 18). Each subject completed a semiquantitative Food Frequency Questionnaire and gave a blood sample. Platelet PL FA composition and MPV were determined by standard methods. MPV was significantly greater in the vegans than in the ovolacto vegetarian, moderate, or high meat-eater groups (P < 0.01). Both vegan and ovolacto vegetarian groups had significantly higher platelet PL 18:2n-6 and 22:4n-6, and lower 20:5n-3 and 22:6n-3 compared with the moderate and high meat-eater groups. The vegans demonstrated a significant reduction in 20:4n-6 and 22:5n-3 compared with the ovolacto vegetarian, high meat-eater, and moderate meat-eater groups. Bivariate analysis results showed that MPV was significantly positively correlated with platelet PL 18:2n-6 (P = 0.048) and negatively correlated with 20:3n-6 (P = 0.02), 20:5n-3 (P = 0.005), and 22:5n-3 (P< 0.0001), respectively. In a multiple linear regression analysis, after controlling for potential confounding factors such as dietary group, age, exercise, body mass index, and dietary polyunsaturated and saturated fat, cholesterol, carbohydrate, and fiber intake, the MPV was still strongly negatively correlated with platelet PL 20:3n-6 (P = 0.003) and 22:5n-3 (P = 0.001). The present data suggest that 22:5n-3 and 20:3n-6 may play a role in the structural function of the platelet membrane.
Language eng
DOI 10.1007/s11745-002-0977-0
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2002, AOCS Press
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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