Short-term diets enriched in stearic or palmitic acids do not alter plasma lipids, platelet aggregation or platelet activation status Kelly, F. D., Sinclair, Andrew, Mann, N. J., Turner, A. H., Raffin, F. L., Blandford, M. V. and Pike, M. J. 2002, Short-term diets enriched in stearic or palmitic acids do not alter plasma lipids, platelet aggregation or platelet activation status, European journal of clinical nutrition, vol. 56, no. 6, pp. 490-499, doi: 10.1038/sj.ejcn.1601332. Attached Files Name Description MIMEType Size Downloads Title Short-term diets enriched in stearic or palmitic acids do not alter plasma lipids, platelet aggregation or platelet activation status Author(s) Kelly, F. D. Sinclair, Andrew Mann, N. J. Turner, A. H. Raffin, F. L. Blandford, M. V. Pike, M. J. Journal name European journal of clinical nutrition Volume number 56 Issue number 6 Start page 490 End page 499 Publisher Nature Publishing Group Place of publication London, England Publication date 2002-06 ISSN 0954-3007 1476-5640 Keyword(s) stearic acid platelet fatty acid composition platelet aggregation mean platelet volume platelet activation status Summary Objective: To determine whether healthy males who consumed increased amounts of dietary stearic acid compared with increased dietary palmitic acid through the consumption of commercially available foods, exhibited any changes in plasma lipids, platelet aggregation or platelet activation status. Design: A randomised cross-over dietary intervention. Subjects and interventions: Nine free-living healthy males consumed two experimental diets (stearic acid enriched, diet S, and palmitic acid enriched, diet P) for 3 weeks in a randomised cross-over design separated by a 3 week washout phase. The diets consisted of 30% of energy as fat (30% of which was derived from the treatment diets) providing 13 g=day as stearic acid and 17 g=day as palmitic acid on diet S and 7g=day as stearic acid and 22 g=day as palmitic acid on diet P. The dietary ratio of stearic to palmitic acids was 0.76 on diet S compared with 0.31 on diet P. Blood samples were collected on days 0 and 21 of each dietary period. Results: LDL cholesterol levels and platelet aggregation response to the agonist ADP were significantly decreased (P <0.025) in subjects on diet S compared with day 0. Apart from that, there were no significant changes in plasma lipids, plateletaggregation, mean platelet volume and platelet reactivity between diets. There were no significant changes in stearic or palmitic acid levels in plasma phospholipid or triacylglycerol. There was a significant difference in palmitic acid levels in platelet phospholipids between the two diets. Conclusions: Use of commonly available foods led to a 27% increase in stearic acid (diet S) and a 19% increase in palmitic acid (diet P), on diets S and P respectively, and no significant differences between the two diets in plasma lipoprotein concentrations, platelet aggregation or platelet activation status. Language eng DOI 10.1038/sj.ejcn.1601332 Field of Research 111199 Nutrition and Dietetics not elsewhere classified HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2002, Nature Publishing Group Persistent URL http://hdl.handle.net/10536/DRO/DU:30009198 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connected to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Mon, 16 Jun 2014, 10:04:29 EST Wed, 06 Nov 2019, 23:38:39 EST Sun, 17 Apr 2022, 18:36:47 EST Filtered Full Citation counts:   Cited 32 times in TR Web of Science Cited 40 times in Scopus Search Google Scholar Access Statistics: 928 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 13 Oct 2008, 15:54:04 EST