Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression Kitajka, Klara, Sinclair, Andrew, Weisinger, Richard. S., Weisinger, Harrison. S., Mathai, Michael. L, Jayasooriya, Anura. P., Halver, John. E. and Puskas, Laszlo 2004, Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression, Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 30, pp. 10931-10936, doi: 10.1073/pnas.0402342101. Attached Files Name Description MIMEType Size Downloads Title Effects of dietary omega-3 polyunsaturated fatty acids on brain gene expression Author(s) Kitajka, Klara Sinclair, Andrew Weisinger, Richard. S. Weisinger, Harrison. S. Mathai, Michael. L Jayasooriya, Anura. P. Halver, John. E. Puskas, Laszlo Journal name Proceedings of the National Academy of Sciences of the United States of America Volume number 101 Issue number 30 Start page 10931 End page 10936 Publisher National Academy of Sciences Place of publication Washington D.C. Publication date 2004-07-27 ISSN 0027-8424 1091-6490 Summary Polyunsaturated fatty acids (PUFA) are essential structural components of the central nervous system. Their role in controlling learning and memory has been well documented. A nutrigenomic approach with high-density microarrays was used to reveal brain gene-expression changes in response to different PUFA-enriched diets in rats. In aged rats fed throughout life with PUFA-enriched diets, genes with altered expressions included transthyretin, α-synuclein, and calmodulins, which play important roles in synaptic  plasticity and learning. The effect of perinatal omega-3 PUFA supply on gene expression later in life also was studied. Several genes showed similar changes in expression in rats fed omega-3-deficient diets in the perinatal period, regardless of whether they or their mothers were fed omega-3 PUFA-sufficient diets after giving birth. In this experiment, among the down-regulated genes were a kainate glutamate receptor and a DEAD-box polypeptide. Among the up-regulated genes were a chemokine-like factor, a tumor necrosis factor receptor, and cytochrome c. The possible involvement of the genes with altered expression attributable to different diets in different brain regions in young and aged rats and the possible mode of regulatory action of PUFA also are discussed. We conclude that PUFA-enriched diets lead to significant changes in expression of several genes in the central nervous tissue, and these effects appear to be mainly independent of their effects on membrane composition. The direct effects of PUFA on transcriptional modulators, the downstream developmentally and tissue-specifically activated elements might be one of the clues to understanding the beneficial effects of the omega-3 PUFA on the nervous system. Language eng DOI 10.1073/pnas.0402342101 Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified HERDC Research category C1.1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2004, National Academy of Sciences of the USA Persistent URL http://hdl.handle.net/10536/DRO/DU:30009403 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 21 Jan 2009, 14:19:10 EST Thu, 11 Jun 2009, 12:09:41 EST Mon, 16 Jun 2014, 10:16:17 EST Thu, 07 Nov 2019, 00:35:46 EST Sat, 19 Mar 2022, 06:37:08 EST Filtered Full Citation counts:   Cited 234 times in TR Web of Science Cited 258 times in Scopus Search Google Scholar Access Statistics: 966 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 13 Oct 2008, 15:59:51 EST