A significant inverse relationship between concentrations of plasma hoocysteine and phospholipid docosahexaenoic acid in healthy male subjects Li, Duo, Mann, Neil J. and Sinclair, Andrew 2006, A significant inverse relationship between concentrations of plasma hoocysteine and phospholipid docosahexaenoic acid in healthy male subjects, Lipids, vol. 41, no. 1, pp. 85-89, doi: 10.1007/s11745-006-5074-x. Attached Files Name Description MIMEType Size Downloads Title A significant inverse relationship between concentrations of plasma hoocysteine and phospholipid docosahexaenoic acid in healthy male subjects Author(s) Li, Duo Mann, Neil J. Sinclair, Andrew Journal name Lipids Volume number 41 Issue number 1 Start page 85 End page 89 Publisher Springer Place of publication Berlin, Germany Publication date 2006-01 ISSN 0024-4201 1558-9307 Keyword(s) Lipids Summary The aim of this study was to investigate the possibility of a relationship between plasma homocysteine (Hcy) and phospholipid FA (PUFA) in healthy Australian males. One hundred thirty six healthy male subjects aged 20–55 yr were recruited from the Melbourne metropolitan area. Each volunteer completed a semiquantitative food frequency questionnaire and gave a blood sample. Plasma Hcy concentrations were determined by an established HPLC method; the plasma phospholipid FA were determined by standard methods. Plasma Hcy concentration was significantly negatively correlated with plasma phospholipid concentration of the PUFA 20∶5n−3 (r=−0.226, P=0.009), 22∶5n−3 (r=−0.182, P=0.036), 22∶6n−3 (r=−0.286, P=0.001), total n−3 (r=−0.270, P=0.002) and the ratio n−3/n−6 PUFA (r=−0.265, P=0.002), and significantly positively correlated with 20∶4n−6 (r=0.180, P=0.037). In the partial correlation analysis, after controlling for serum vitamin B12 and folate concentration, plasma Hcy was significantly negatively correlated with the plasma phospholipid concentration of 22∶6n−3 (r=−0.205, P=0.019), total n−3 (r=−0.182, P=0.038) and the ratio n−3/n−6 PUFA (r=−0.174, P=0.048). Evidence indicates that an increased concentration of n−3 PUFA in tissues has a beneficial effect on cardiovascular health. Our findings provide further evidence that increased consumption of dietary n−3 PUFA increases the concentration of n−3 PUFA in plasma phospholipid, which is associated with a protective effect on cardiovascular diseases and lower plasma Hcy levels. The mechanism that might explain the association between plasma 22∶6n−3 and Hcy levels is not clear. Language eng DOI 10.1007/s11745-006-5074-x Field of Research 069999 Biological Sciences not elsewhere classified HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2006, AOCS Press Persistent URL http://hdl.handle.net/10536/DRO/DU:30009412 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 17 Dec 2008, 12:39:08 EST Mon, 11 Apr 2011, 16:32:18 EST Mon, 16 Jun 2014, 10:16:58 EST Filtered Full Citation counts:   Cited 50 times in TR Web of Science Cited 48 times in Scopus Search Google Scholar Access Statistics: 1040 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Mon, 13 Oct 2008, 16:00:04 EST