A randomized trial of protocol-directed sedation management for mechanical ventilation in an Australian intensive care unit

Bucknall, Tracey K., Manias, Elizabeth and Presneill, Jeffrey J. 2008, A randomized trial of protocol-directed sedation management for mechanical ventilation in an Australian intensive care unit, Critical care medicine, vol. 36, no. 5, pp. 1444-1450, doi: 10.1097/CCM.0b013e318168f82d.

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Title A randomized trial of protocol-directed sedation management for mechanical ventilation in an Australian intensive care unit
Author(s) Bucknall, Tracey K.ORCID iD for Bucknall, Tracey K. orcid.org/0000-0001-9089-3583
Manias, ElizabethORCID iD for Manias, Elizabeth orcid.org/0000-0002-3747-0087
Presneill, Jeffrey J.
Journal name Critical care medicine
Volume number 36
Issue number 5
Start page 1444
End page 1450
Total pages 7
Publisher Lippincott Williams & Wilkins
Place of publication Baltimore, Md.
Publication date 2008-05
ISSN 0090-3493
Keyword(s) ventilator weaning
clinical decision making
clinical protocols
intensive care
outcome and process assessment (health care)
hypnotics and sedatives
Summary Objective: To compare protocol-directed sedation management with traditional non-protocol-directed practice in mechanically ventilated patients. Design: Randomized, controlled trial. Setting: General intensive care unit (24 beds) in an Australian metropolitan teaching hospital. Patients: Adult, mechanically ventilated patients (n = 312). Interventions: Patients were randomly assigned to receive sedation directed by formal guidelines (protocol group, n = 153) or usual local clinical practice (control, n = 159). Measurements and Main Results: The median (95% confidence interval) duration of ventilation was 79 hrs (56-93 hrs) for patients in the protocol group compared with 58 hrs (44-78 hrs) for patients who received control care (p = .20). Lengths of stay (median [range]) in the intensive care unit (94 [2-1106] hrs vs. 88 (14-962) hrs, p = .58) and hospital (13 [1-113] days vs. 13 (1-365) days, p = .97) were similar, as were the proportions of subjects receiving a tracheostomy (17% vs. 15%, p = .64) or undergoing unplanned self-extubation (1.3% vs. 0.6%, p = .61). Death in the intensive care unit occurred in 32 (21%) patients in the protocol group and 32 (20%) control subjects (p = .89), with a similar overall proportion of deaths in hospital (25% vs. 22%, p = .51). A Cox proportional hazards model, after adjustment for age, gender, Acute Physiology and Chronic Health Evaluation II score, diagnostic category, and doses of commonly used drugs, estimated that protocol sedation management was associated with a 22% decrease (95% confidence interval 40% decrease to 2% increase, p = .07) in the occurrence of successful weaning from mechanical ventilation. Conclusions: This randomized trial provided no evidence of a substantial reduction in the duration of mechanical ventilation or length of stay, in either the intensive care unit or the hospital, with the use of protocol-directed sedation compared with usual local management. Qualified high-intensity nurse staffing and routine Australian intensive care unit nursing responsibility for many aspects of ventilatory practice may explain the contrast between these findings and some recent North American studies. (C) 2008 Lippincott Williams & Wilkins, Inc.
Notes School of Nursing
Language eng
DOI 10.1097/CCM.0b013e318168f82d
Field of Research 111003 Clinical Nursing: Secondary (Acute Care)
Socio Economic Objective 920210 Nursing
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2008, Lippincott, Williams & Wilkins
Persistent URL http://hdl.handle.net/10536/DRO/DU:30017895

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