Fenitrothion, an organophosphate, affects running endurance but not aerobic capacity in fat-tailed dunnarts (Sminthopsis crassicaudata) Buttemer, William A., Story, Paul G., Fildes, Karen J., Baudinette, Russell V. and Astheimer, Lee B. 2008, Fenitrothion, an organophosphate, affects running endurance but not aerobic capacity in fat-tailed dunnarts (Sminthopsis crassicaudata), Chemosphere, vol. 72, no. 9, pp. 1315-1320, doi: 10.1016/j.chemosphere.2008.04.054. Attached Files Name Description MIMEType Size Downloads Title Fenitrothion, an organophosphate, affects running endurance but not aerobic capacity in fat-tailed dunnarts (Sminthopsis crassicaudata) Formatted title Fenitrothion, an organophosphate, affects running endurance but not aerobic capacity in fat-tailed dunnarts (Sminthopsis crassicaudata) Author(s) Buttemer, William A. Story, Paul G. Fildes, Karen J. Baudinette, Russell V. Astheimer, Lee B. Journal name Chemosphere Volume number 72 Issue number 9 Start page 1315 End page 1320 Total pages 6 Publisher Elsevier Place of publication Amsterdam, The Netherlands Publication date 2008-07 ISSN 0045-6535 1879-1298 Keyword(s) marsupial organophosphate oxygen consumption running endurance thermogenesis fenitrothion Summary We measured aerobic metabolism during cold exposure and exercise performance (run duration and oxygen consumption while running at 1 m s−1) in the fat-tailed dunnart Sminthopsis crassicaudata, a dasyurid marsupial, before and after ingestion of 30 mg kg−1 of fenitrothion, an organophosphate (OP) pesticide. Running endurance of OP-exposed animals was less than half that of control animals over the first 3 days after dosing and 55% of control animal endurance on day 5 post-dose. Despite these declines, peak metabolic rate at this running speed (9.3 times basal metabolic rate; BMR) was unaffected by OP exposure. Peak metabolic rate (PMR) and cumulative oxygen consumption during a 1-h exposure to conditions equivalent to −20 °C did not differ between OP-treated and control dunnarts, with PMR averaging 11 times BMR. We conclude that fenitrothion-induced exercise fatigue is not due to limitations in oxygen or substrate delivery to muscle or in their uptake per se, but more likely relates to decreased ability to sustain high-frequency neuromuscular function. The persistence of locomotor impairment following OP exposure in otherwise asymptomatic animals emphasizes the importance of using performance-based measures when characterising sublethal effects of pesticide exposure in an ecological context. Language eng DOI 10.1016/j.chemosphere.2008.04.054 Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences HERDC Research category C1.1 Refereed article in a scholarly journal HERDC collection year 2008 Copyright notice ©2008, Elsevier Persistent URL http://hdl.handle.net/10536/DRO/DU:30018647 Document type: Journal Article Collections: Faculty of Science, Engineering and Built Environment School of Life and Environmental Sciences Office of the Deputy Vice-Chancellor (Research) Centre for Integrative Ecology Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Thu, 10 Sep 2009, 14:45:45 EST Thu, 10 Sep 2009, 14:55:54 EST Thu, 10 Sep 2009, 14:57:38 EST Mon, 16 Nov 2009, 14:16:25 EST Tue, 17 Nov 2009, 08:51:10 EST Tue, 24 Nov 2009, 10:26:27 EST Fri, 10 Jan 2014, 09:11:32 EST Mon, 16 Jun 2014, 12:39:10 EST Thu, 11 Dec 2014, 16:13:07 EST Filtered Full Citation counts:   Cited 16 times in TR Web of Science Cited 20 times in Scopus Search Google Scholar Access Statistics: 704 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Thu, 10 Sep 2009, 14:45:44 EST by Leanne Swaneveld