Potential role of nitric oxide in contraction-stimulated glucose uptake and mitochondrial biogenesis in skeletal muscle McConell, Glenn K. and Wadley, Glenn D. 2008, Potential role of nitric oxide in contraction-stimulated glucose uptake and mitochondrial biogenesis in skeletal muscle, Clinical and experimental pharmacology and physiology, vol. 35, no. 12, pp. 1488-1492, doi: 10.1111/j.1440-1681.2008.05038.x. Attached Files Name Description MIMEType Size Downloads Title Potential role of nitric oxide in contraction-stimulated glucose uptake and mitochondrial biogenesis in skeletal muscle Author(s) McConell, Glenn K. Wadley, Glenn D. orcid.org/0000-0002-6617-4359 Journal name Clinical and experimental pharmacology and physiology Volume number 35 Issue number 12 Start page 1488 End page 1492 Total pages 5 Publisher Blackwell Scientific Place of publication Oxford, England Publication date 2008-12 ISSN 0305-1870 1440-1681 Keyword(s) AMP-activated protein kinase contraction exercise glucose metabolism glucose uptake mitochondria mitochondrial biogenesis nitric oxide reactive oxygen species skeletal muscle Summary • 1. The present review discusses the potential role of nitric oxide (NO) in the: (i) regulation of skeletal muscle glucose uptake during exercise; and (ii) activation of mitochondrial biogenesis after exercise. • 2. We have shown in humans that local infusion of an NO synthase inhibitor during exercise attenuates increases in skeletal muscle glucose uptake without affecting blood flow. Recent studies from our laboratory in rodents support these findings in humans, although rodent studies from other laboratories have yielded conflicting results. • 3. There is clear evidence that NO increases mitochondrial biogenesis in non-contracting cells and that NO influences basal skeletal muscle mitochondrial biogenesis. However, there have been few studies examining the potential role of NO in the activation of mitochondrial biogenesis following an acute bout of exercise or in response to exercise training. Early indications are that NO is not involved in regulating the increase in mitochondrial biogenesis that occurs in response to exercise. • 4. Exercise is considered the best prevention and treatment option for diabetes, but unfortunately many people with diabetes do not or cannot exercise regularly. Alternative therapies are therefore critical to effectively manage diabetes. If skeletal muscle NO is found to play an important role in regulating glucose uptake and/or mitochondrial biogenesis, pharmaceutical agents designed to mimic these effects of exercise may improve glycaemic control. Language eng DOI 10.1111/j.1440-1681.2008.05038.x Field of Research 110699 Human Movement and Sports Science not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2008, Wiley-Blackwell Publishing Persistent URL http://hdl.handle.net/10536/DRO/DU:30019389 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Institute for Physical Activity and Nutrition Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 11 Sep 2009, 15:57:29 EST Fri, 11 Sep 2009, 16:01:19 EST Tue, 15 Sep 2009, 13:55:15 EST Tue, 15 Sep 2009, 14:22:45 EST Wed, 16 Sep 2009, 08:51:01 EST Wed, 16 Sep 2009, 08:52:08 EST Fri, 27 Nov 2009, 13:28:59 EST Fri, 27 Nov 2009, 16:12:05 EST Tue, 12 Nov 2013, 11:22:42 EST Mon, 16 Jun 2014, 12:47:28 EST Wed, 27 Aug 2014, 22:02:51 EST Thu, 11 Dec 2014, 16:13:46 EST Filtered Full Citation counts:   Cited 24 times in TR Web of Science Cited 24 times in Scopus Search Google Scholar Access Statistics: 863 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Fri, 11 Sep 2009, 15:57:28 EST