L-Arginine infusion increases glucose clearance during prolonged exercise in humans McConell, G.K., Huynh, N. N., Lee-Young, R.S., Canny, B. J. and Wadley, G.D. 2006, L-Arginine infusion increases glucose clearance during prolonged exercise in humans, American journal of physiology : endocrinology and metabolism, vol. 290, no. 1, pp. E60-E66, doi: 10.1152/ajpendo.00263.2005. Attached Files Name Description MIMEType Size Downloads Title L-Arginine infusion increases glucose clearance during prolonged exercise in humans Author(s) McConell, G.K. Huynh, N. N. Lee-Young, R.S. Canny, B. J. Wadley, G.D. orcid.org/0000-0002-6617-4359 Journal name American journal of physiology : endocrinology and metabolism Volume number 290 Issue number 1 Start page E60 End page E66 Publisher American Physiological Society Place of publication Bethesda, Md. Publication date 2006-01 ISSN 0193-1849 1522-1555 Keyword(s) nitric oxide glucose kinetics contraction Summary Nitric oxide synthase (NOS) inhibition has been shown in humans to attenuate exercise-induced increases in muscle glucose uptake. We examined the effect of infusing the NO precursor L-arginine (L-Arg) on glucose kinetics during exercise in humans. Nine endurance-trained males cycled for 120 min at 72 ± 1% VO2 peak followed immediately by a 15-min "all-out" cycling performance bout. A [6,6-2H]glucose tracer was infused throughout exercise, and either saline alone (Control, CON) or saline containing L-Arg HCl (L-Arg, 30 g at 0.5 g/min) was coinfused in a double-blind, randomized order during the last 60 min of exercise. L-Arg augmented the increases in glucose rate of appearance, glucose rate of disappearance, and glucose clearance rate (L-Arg: 16.1 ± 1.8 ml·min–1·kg–1; CON: 11.9 ± 0.7 ml·min–1·kg–1 at 120 min, P < 0.05) during exercise, with a net effect of reducing plasma glucose concentration during exercise. L-Arg infusion had no significant effect on plasma insulin concentration but attenuated the increase in nonesterified fatty acid and glycerol concentrations during exercise. L-Arg infusion had no effect on cycling exercise performance. In conclusion, L-Arg infusion during exercise significantly increases skeletal muscle glucose clearance in humans. Because plasma insulin concentration was unaffected by L-Arg infusion, greater NO production may have been responsible for this effect. Language eng DOI 10.1152/ajpendo.00263.2005 Field of Research 110899 Medical Microbiology not elsewhere classified Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1.1 Refereed article in a scholarly journal Copyright notice ©2006, American Physiological Society Persistent URL http://hdl.handle.net/10536/DRO/DU:30019472 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Institute for Physical Activity and Nutrition Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Tue, 15 Sep 2009, 16:02:43 EST Wed, 16 Sep 2009, 14:43:13 EST Thu, 17 Sep 2009, 15:52:59 EST Thu, 17 Sep 2009, 15:54:32 EST Fri, 16 Oct 2009, 09:24:02 EST Fri, 27 Nov 2009, 16:07:32 EST Tue, 01 Dec 2009, 10:24:05 EST Tue, 12 Nov 2013, 11:26:04 EST Mon, 16 Jun 2014, 12:50:47 EST Wed, 27 Aug 2014, 22:03:53 EST Filtered Full Citation counts:   Cited 42 times in TR Web of Science Cited 50 times in Scopus Search Google Scholar Access Statistics: 1026 Abstract Views, 0 File Downloads  -  Detailed Statistics Created: Tue, 15 Sep 2009, 16:02:43 EST