Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy

Davidson, Philip W., Strain, JJ, Myers, Gary J., Thurston, Sally W., Bonham, Maxine P, Shamlaye, Conrad F., Stokes-Riner, Abbie, Wallace, Julie M.W., Robson, Paula J., Duffy, Emeir M, Georger, Lesley A., Sloane-Reeves, Jean, Cernichiari, Elsa, Canfield, Richard L., Cox, Christopher, Huang, Li Shan, Janciuras, Joanne and Clarkson, Thomas W. 2008, Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy, NeuroToxicology, vol. 29, no. 5, pp. 767-775, doi: 10.1016/j.neuro.2008.06.001.

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Title Neurodevelopmental effects of maternal nutritional status and exposure to methylmercury from eating fish during pregnancy
Author(s) Davidson, Philip W.
Strain, JJ
Myers, Gary J.
Thurston, Sally W.
Bonham, Maxine P
Shamlaye, Conrad F.
Stokes-Riner, Abbie
Wallace, Julie M.W.
Robson, Paula J.
Duffy, Emeir M
Georger, Lesley A.
Sloane-Reeves, Jean
Cernichiari, Elsa
Canfield, Richard L.
Cox, Christopher
Huang, Li Shan
Janciuras, Joanne
Clarkson, Thomas W.
Journal name NeuroToxicology
Volume number 29
Issue number 5
Start page 767
End page 775
Publisher Elsevier Inc.
Place of publication Amsterdam, Netherlands
Publication date 2008-09
ISSN 0161-813X
Keyword(s) prenatal methyl mercury
child development
fish consumption
maternal nutritional status
Seychelles Child Development Study (SCDS)
Summary Fish contain nutrients that promote optimal brain growth and development but also contain methylmercury (MeHg) that can have toxic effects. The present study tested the hypothesis that the intake of selected nutrients in fish or measures of maternal nutritional status may represent important confounders when estimating the effects of prenatal methylmercury exposure on child development. The study took place in the Republic of Seychelles, an Indian Ocean archipelago where fish consumption is high. A longitudinal cohort study design was used. A total of 300 mothers were enrolled early in pregnancy. Nutrients considered to be important for brain development were measured during pregnancy along with prenatal MeHg exposure. The children were evaluated periodically to age 30 months. There were 229 children with complete outcome and covariate data for analysis. The primary endpoint was the Bayley Scales of Infant Development-II (BSID-II), administered at 9 and 30 months of age. Combinations of four secondary measures of infant cognition and memory were also given at 5, 9 and 25 months. Cohort mothers consumed an average of 537 g of fish (nine meals containing fish) per week. The average prenatal MeHg exposure was 5.9 ppm in maternal hair. The primary analysis examined the associations between MeHg, maternal nutritional measures and children's scores on the BSID-II and showed an adverse association between MeHg and the mean Psychomotor Developmental Index (PDI) score at 30 months. Secondary analyses of the association between the PDI and only MeHg alone or nutritional factors alone showed only a borderline significant association between MeHg and the PDI at 30 months and no associations with nutritional factors. One experimental measure at 5 months of age was positively associated with iodine status, but not prenatal MeHg exposure. These findings suggest a possible confounding role of maternal nutrition in studies examining associations between prenatal MeHg exposures and developmental outcomes in children.
Language eng
DOI 10.1016/j.neuro.2008.06.001
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
HERDC collection year 2008
Copyright notice ©2008, Elsevier Inc.
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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