Vitamin D: status, supplementation and immuno-modulation

Barnes, Maria S., Robson, Paula J., Bonham, Maxine P, Strain, JJ and Wallace, Julie M.W. 2006, Vitamin D: status, supplementation and immuno-modulation, Current nutrition and food science,, vol. 2, no. 4, pp. 315-336, doi: 10.2174/157340106778699403.

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Title Vitamin D: status, supplementation and immuno-modulation
Author(s) Barnes, Maria S.
Robson, Paula J.
Bonham, Maxine P
Strain, JJ
Wallace, Julie M.W.
Journal name Current nutrition and food science,
Volume number 2
Issue number 4
Start page 315
End page 336
Publisher Bentham Science Publishers
Place of publication Bussum, The Netherlands
Publication date 2006-11
ISSN 1573-4013
Keyword(s) vitamin D
vitamin D status
vitamin D supplementation
multiple sclerosis
autoimmune disease
Summary Numerous studies have shown suboptimal vitamin D status in populations at high geographical latitudes, owing to a reduced capacity to synthesise vitamin D, especially during wintertime. Vitamin D supplementation has been shown to be effective at maintaining adequate vitamin D status throughout the year in these countries. Classically reported to play a central role in bone health, vitamin D has more recently been shown to modulate immune function by promoting an anti-inflammatory response, which may be related to onset or progression of autoimmune inflammatory disorders. One such condition is multiple sclerosis (MS). There is an increasing incidence of MS with increasing latitude, with higher prevalence reported in countries further away from the equator, where vitamin D synthesis is inadequate. Vitamin D has been shown to have positive effects on the animal model of MS, experimental autoimmune encephalomyelitis. However, there have been few human intervention studies to investigate the effect of vitamin D supplementation on symptoms of MS or indeed of other autoimmune disorders. Further research is required to examine the potential beneficial role of vitamin D in MS to ultimately determine the optimal vitamin D status required to alleviate symptoms and possibly prevent this and other chronic diseases.
Language eng
DOI 10.2174/157340106778699403
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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