Improved endothelial function following a 14 month resistance exercise training program in adults with type 2 diabetes

Cohen, N. D., Dunstan, D. W., Robinson, C., Vulikh, E., Zimmet, P. Z. and Shaw, J. E. 2008, Improved endothelial function following a 14 month resistance exercise training program in adults with type 2 diabetes, Diabetes research and clinical practice, vol. 79, no. 3, pp. 405-411, doi: 10.1016/j.diabres.2007.09.020.

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Title Improved endothelial function following a 14 month resistance exercise training program in adults with type 2 diabetes
Author(s) Cohen, N. D.
Dunstan, D. W.
Robinson, C.
Vulikh, E.
Zimmet, P. Z.
Shaw, J. E.
Journal name Diabetes research and clinical practice
Volume number 79
Issue number 3
Start page 405
End page 411
Publisher Elsevier Science Publishers B.V.
Place of publication Amsterdam, Netherlands
Publication date 2008-03
ISSN 0168-8227
Keyword(s) type 2 diabetes
resistance training
Summary Objective
We examined the effect of a 14-month progressive resistance training (PRT) program on endothelial function in both a supervised training (Center) group and non-supervised training (Home) group of patients with type 2 diabetes. We studied 28 men and women with type 2 diabetes who participated in a 14-month PRT involving an initial 2-month supervised program and a 12-month maintenance program.

Endothelial function testing was performed through laser doppler flow responses in the skin microcirculation to iontophoresis of acetylcholine (ACh) and sodium nitroprusside (NaNP) and doses of 4, 8 and 16 mC were used. Measurements of vascular response (VR), HbA1c, weight and blood pressure were performed at 0, 2 and 14 months.

VR to ACh and NaNP was significantly increased at 14 months compared with baseline in both the Center and Home groups. However, no between-group differences were observed. A significant correlation was observed between HbA1c and VR to ACh at baseline and 8 weeks using 8 mC dose of ACh. There was a strong correlation between HbA1c at baseline and VR at 14 months using all three doses of ACh (4 mC:r = −0.546, p = 0.003, 8 mC:r = −0.470, p = 0.002, 16 mC:r = −0.547, p = 0.006).

Endothelial function is improved following 14 months of PRT in type 2 diabetes both in a supervised and non-supervised program. Strong correlations with HbA1c including initial HbA1c levels suggest that glycemic control may be an important factor in long-term regulation of endothelial function.
Language eng
DOI 10.1016/j.diabres.2007.09.020
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2007, Elsevier Ireland Ltd
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Document type: Journal Article
Collections: Faculty of Health
School of Exercise and Nutrition Sciences
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