Life and death : metabolic rate, membrane composition, and life span of animals

Hulbert, A.J., Pamplona, Reinald, Buffenstein, Rochelle and Buttemer, W.A. 2007, Life and death : metabolic rate, membrane composition, and life span of animals, Physiological reviews, vol. 87, no. 4, pp. 1175-1213, doi: 10.1152/physrev.00047.2006.

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Title Life and death : metabolic rate, membrane composition, and life span of animals
Author(s) Hulbert, A.J.
Pamplona, Reinald
Buffenstein, Rochelle
Buttemer, W.A.
Journal name Physiological reviews
Volume number 87
Issue number 4
Start page 1175
End page 1213
Publisher American Physiological Society
Place of publication Washington, D.C.
Publication date 2007-10
ISSN 0031-9333
Summary Maximum life span differences among animal species exceed life span variation achieved by experimental manipulation by orders of magnitude. The differences in the characteristic maximum life span of species was initially proposed to be due to variation in mass-specific rate of metabolism. This is called the rate-of-living theory of aging and lies at the base of the oxidative-stress theory of aging, currently the most generally accepted explanation of aging. However, the rate-of-living theory of aging while helpful is not completely adequate in explaining the maximum life span. Recently, it has been discovered that the fatty acid composition of cell membranes varies systematically between species, and this underlies the variation in their metabolic rate. When combined with the fact that 1) the products of lipid peroxidation are powerful reactive molecular species, and 2) that fatty acids differ dramatically in their susceptibility to peroxidation, membrane fatty acid composition provides a mechanistic explanation of the variation in maximum life span among animal species. When the connection between metabolic rate and life span was first proposed a century ago, it was not known that membrane composition varies between species. Many of the exceptions to the rate-of-living theory appear explicable when the particular membrane fatty acid composition is considered for each case. Here we review the links between metabolic rate and maximum life span of mammals and birds as well as the linking role of membrane fatty acid composition in determining the maximum life span. The more limited information for ectothermic animals and treatments that extend life span (e.g., caloric restriction) are also reviewed.
Language eng
DOI 10.1152/physrev.00047.2006
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007, American Physiological Society
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