Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more Liongue, Clifford, Wright, Craig, Russell, Aaron P. and Ward, Alister C. 2009, Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more, International journal of biochemistry and cell biology, vol. 41, no. 12, pp. 2372-2375, doi: 10.1016/j.biocel.2009.08.011. Attached Files Name Description MIMEType Size Downloads Title Granulocyte colony-stimulating factor receptor: stimulating granulopoiesis and much more Author(s) Liongue, Clifford orcid.org/0000-0002-1646-4905 Wright, Craig orcid.org/0000-0001-7903-3144 Russell, Aaron P. orcid.org/0000-0002-7323-9501 Ward, Alister C. orcid.org/0000-0001-7945-7975 Journal name International journal of biochemistry and cell biology Volume number 41 Issue number 12 Start page 2372 End page 2375 Total pages 4 Publisher Elsevier Ltd. Place of publication Amsterdam, The Netherlands Publication date 2009-12 ISSN 1357-2725 1878-5875 Keyword(s) G-CSF cytokine receptor hematopoiesis signaling Summary The granulocyte colony-stimulating factor receptor (G-CSFR) plays an important role in the production, survival and activation of neutrophilic granulocytes during both normal and emergency hematopoiesis. The G-CSFR also participates in the development of other myeloid lineages, the mobilization of hematopoietic stem cells and myeloid cell migration. This has lead to several important clinical applications for its ligand, G-CSF. More recently, additional important roles for G-CSFR have emerged outside the hematopoietic system, such as in the protection and repair of a diverse range of tissues, including muscle, liver and neural tissue, providing further scope for developing G-CSF as a therapeutic agent. The G-CSFR has also been implicated in the etiology of disease, with mutations/variants of G-CSFR implicated in neutropenia, myelodysplasia and leukemia. Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis. Language eng DOI 10.1016/j.biocel.2009.08.011 Field of Research 110707 Innate Immunity Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2009, Elsevier Ltd. Persistent URL http://hdl.handle.net/10536/DRO/DU:30022875 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences School of Medicine Institute for Physical Activity and Nutrition Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Wed, 03 Feb 2010, 13:39:56 EST Thu, 04 Feb 2010, 13:15:09 EST Thu, 04 Feb 2010, 13:16:25 EST Thu, 04 Feb 2010, 13:17:13 EST Thu, 04 Feb 2010, 13:25:06 EST Thu, 04 Feb 2010, 13:26:31 EST Fri, 05 Feb 2010, 10:15:01 EST Wed, 24 Feb 2010, 15:42:30 EST Wed, 03 Mar 2010, 12:54:18 EST Mon, 20 Feb 2012, 11:47:57 EST Tue, 06 Mar 2012, 11:08:52 EST Tue, 10 Dec 2013, 14:48:36 EST Mon, 16 Jun 2014, 14:17:08 EST Wed, 02 Jul 2014, 14:04:15 EST Fri, 17 Oct 2014, 10:04:00 EST Filtered Full Citation counts:   Cited 68 times in TR Web of Science Cited 72 times in Scopus Search Google Scholar Access Statistics: 1969 Abstract Views, 3 File Downloads  -  Detailed Statistics Created: Wed, 03 Feb 2010, 13:39:55 EST by Sally Morrigan