Antigenic relationships between bluetongue virus serotypes as defined by monoclonal antibodies
White, John R., Ph.D. 1992, Antigenic relationships between bluetongue virus serotypes as defined by monoclonal antibodies, Ph.D. thesis, Deakin University.
Panels of monoclonal antibodies (MAbs) were generated to individual proteins of an Australian isolate of bluetongue virus (BTV) serotype 1 (VP2, VP3, VP5, VP6, NS1 and NS2). The number of individual epitopes and antigenic regions each panel defined were then determined. The simultaneous reaction of certain neutralization-resistant variants and heterologous serotyoes with several MAbs specific for such epitopes, resulted in low level virus neutralization.
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