Incorporation and metabolism of punicic acid in healthy young humans Yuan, Gaofeng, Sinclair, Andrew J., Xu, Chaojiong and Li, Duo 2009, Incorporation and metabolism of punicic acid in healthy young humans, Molecular nutrition and food research, vol. 53, no. 10, pp. 1336-1342, doi: 10.1002/mnfr.200800520. Attached Files Name Description MIMEType Size Downloads Title Incorporation and metabolism of punicic acid in healthy young humans Author(s) Yuan, Gaofeng Sinclair, Andrew J. Xu, Chaojiong Li, Duo Journal name Molecular nutrition and food research Volume number 53 Issue number 10 Start page 1336 End page 1342 Total pages 7 Publisher Wiley Place of publication Weinheim, Germany Publication date 2009-10 ISSN 1613-4125 1613-4133 Summary The objective of this study was to investigate the incorporation and metabolism of punicic acid (PA, cis9,trans11,cis13-18:3) in healthy young humans. The study was a randomized controlled trial. After 7 days adaptation with sunflower seed kernels supplementation, 30 subjects were then divided into the control and test group (n = 15). The test group was supplemented with Trichosanthes kirilowii (TK) seed kernels containing 3 g of PA per day in the form of triacylglycerols for 28 days. The control group was provided with sunflower seed kernels. After consumption of TK seeds containing 3 g PA per day for 28 days, the proportion of PA was increased from 0.00 to 0.47% in plasma and 0.00 to 0.37% in red blood cell membranes (RBCM), respectively. The proportion of cis9,trans11-18:2 was increased from 0.05 to 0.23% in plasma and 0.03 to 0.17% in RBCM after 28 days of intervention, respectively. Our results suggest that PA can be effectively incorporated into human plasma and RBCM, and is also associated with the increasing proportion of cis9,trans11-18:2 in humans, presumably as a result of metabolism by a saturation reaction. Edible TK seeds could be a potential dietary source of conjugated linoleic acids. Language eng DOI 10.1002/mnfr.200800520 Field of Research 111103 Nutritional Physiology Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2009, Wiley Persistent URL http://hdl.handle.net/10536/DRO/DU:30024885 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 05 Mar 2010, 07:56:20 EST Mon, 22 Mar 2010, 11:08:22 EST Mon, 22 Mar 2010, 11:09:38 EST Wed, 11 Aug 2010, 16:33:27 EST Mon, 20 Feb 2012, 11:36:23 EST Fri, 04 Jul 2014, 13:53:53 EST Thu, 10 Jul 2014, 16:30:23 EST Thu, 10 Jul 2014, 16:31:08 EST Wed, 01 Oct 2014, 15:06:08 EST Filtered Full Citation counts:   Cited 39 times in TR Web of Science Cited 42 times in Scopus Search Google Scholar Access Statistics: 927 Abstract Views, 2 File Downloads  -  Detailed Statistics Created: Fri, 05 Mar 2010, 07:56:12 EST by Sally Morrigan