Do maternally derived antibodies and early immune experience shape the adult immune response?

Addison, BriAnne, Ricklefs, Robert E. and Klasing, Kirk C. 2010, Do maternally derived antibodies and early immune experience shape the adult immune response?, Functional ecology, vol. 24, no. 4, pp. 824-829, doi: 10.1111/j.1365-2435.2010.01706.x.

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Title Do maternally derived antibodies and early immune experience shape the adult immune response?
Author(s) Addison, BriAnne
Ricklefs, Robert E.
Klasing, Kirk C.
Journal name Functional ecology
Volume number 24
Issue number 4
Start page 824
End page 829
Publisher Blackwell Publishing
Place of publication Oxford, England
Publication date 2010-03-19
ISSN 0269-8463
Keyword(s) immunological imprinting
maternal effects
yolk antibodies
Summary 1. Immunological imprinting by maternally derived antibodies has been proposed to have both positive and negative consequences for offspring immunity in early and adult life. However, few studies of maternal effects on immunity have followed individuals past the juvenile stages.

2. Using laboratory Japanese quail, we developed a novel method of directly manipulating yolk antibodies of neonates, and then followed individuals through a series of immune challenges until they were of reproductive age.

3. Our method of directly injecting purified antibodies into the yolk sac of newly hatched chicks successfully elevated the plasma titres of specific anti-KLH IgY in neonates. This allows us to test whether differences in neonatal anti-KLH IgY affect immunity at the juvenile and adult stages of life.

4. We found little evidence for an effect of maternal antibodies on juvenile stage immune response, in contrast to results from previous studies. Adult immune response depended largely on the magnitude of the juvenile immune response regardless of the identity of the antigen in the juvenile immune challenge, and did not depend on neonatal IgY titres. Our results are consistent with a priming effect of early immune experience on adult stage immune responsiveness, but we found no evidence of carryover effects of yolk-derived antibodies on adult immunity.

5. This study employs new methodology for investigation of maternal antibodies and presents results suggesting that further studies of maternal effects on immunity will require careful consideration of the numerous ways maternally derived yolk components can impact the different types of immune response.
Language eng
DOI 10.1111/j.1365-2435.2010.01706.x
Field of Research 110702 Applied Immunology (incl Antibody Engineering, Xenotransplantation and T-cell Therapies)
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2010, The Authors.
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Created: Mon, 08 Mar 2010, 12:14:47 EST by Brianne Addison

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