Compensatory Ability to Null Mutation in Metabolic Networks

Jiang, Da, Zhou, Shuigeng and Chen, Yi-Ping Phoebe 2009, Compensatory Ability to Null Mutation in Metabolic Networks, Biotechnology and bioengineering, vol. 103, no. 2, pp. 361-369, doi: 10.1002/bit.22237.

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Title Compensatory Ability to Null Mutation in Metabolic Networks
Author(s) Jiang, Da
Zhou, Shuigeng
Chen, Yi-Ping Phoebe
Journal name Biotechnology and bioengineering
Volume number 103
Issue number 2
Start page 361
End page 369
Publisher John Wiley & Sons, Inc
Place of publication Malden, Mass.
Publication date 2009-06-01
ISSN 0006-3592
Keyword(s) Metabolic networks
Summary Robustness is an inherent property of biological system. It is still a limited understanding of how it is accomplished at the cellular or molecular level. To this end, this article analyzes the impact degree of each reaction to others, which is defined as the number of cascading failures of following and/or forward reactions when an initial reaction is deleted. By analyzing more than 800 organism’s metabolic networks, it suggests that the reactions with larger impact degrees are likely essential and the universal reactions should also be essential. Alternative metabolic pathways compensate null mutations, which represents that average impact degrees for all organisms are small. Interestingly, average impact degrees of archaea organisms are smaller than other two categories of organisms, eukayote and bacteria, indicating that archaea organisms have strong robustness to resist the various perturbations during the evolution process. The results show that scale-free feature and reaction reversibility contribute to the robustness in metabolic networks. The optimal growth temperature of organism also relates the robust structure of metabolic network.
Language eng
DOI 10.1002/bit.22237
Field of Research 060112 Structural Biology (incl Macromolecular Modelling)
Socio Economic Objective 890299 Computer Software and Services not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2009
Copyright notice ©2008, Wiley Periodicals, Inc.
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