Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate

Loughlin, Wendy A., Murphy, Michelle E., Elson, Kathryn E. and Henderson, Luke C. 2004, Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate, Australian journal of chemistry, vol. 57, no. 3, pp. 227-232, doi: 10.1071/CH03184.

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Title Synthesis of a novel pyrrole oxazole analogue of the insecticide pirate
Author(s) Loughlin, Wendy A.
Murphy, Michelle E.
Elson, Kathryn E.
Henderson, Luke C.ORCID iD for Henderson, Luke C.
Journal name Australian journal of chemistry
Volume number 57
Issue number 3
Start page 227
End page 232
Publisher CSIRO Publishing
Place of publication Collingwood, Vic.
Publication date 2004
ISSN 0004-9425
Summary The pyrrole oxazole 4 is a novel analogue of the broad-spectrum insecticide and miticide pirate 2. The expedient synthesis of pyrrole oxazole 4 in six steps from pyrrole is reported using a synthetic route that could have potential for the solution-phase combinatorial synthesis of analogues. Preliminary biological evaluation of the protected pyrrole oxazole 4 (LD50 1.13 μg mL–1) and the deprotected pyrrole oxazole 5 (LD50 1.06 μg mL–1) for potential cytotoxicity was carried out.
Language eng
DOI 10.1071/CH03184
Field of Research 030503 Organic Chemical Synthesis
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2004, CSIRO
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