A question of self-preservation : immunopathology in influenza virus infection

La Gruta, Nicole L., Kedzierska, Katherine, Stambas, John and Doherty, Peter C. 2007, A question of self-preservation : immunopathology in influenza virus infection, Immunology and Cell Biology, vol. 85, no. 2, pp. 85-92, doi: 10.1038/sj.icb.7100026.

Attached Files
Name Description MIMEType Size Downloads

Title A question of self-preservation : immunopathology in influenza virus infection
Author(s) La Gruta, Nicole L.
Kedzierska, Katherine
Stambas, JohnORCID iD for Stambas, John orcid.org/0000-0002-5690-2551
Doherty, Peter C.
Journal name Immunology and Cell Biology
Volume number 85
Issue number 2
Start page 85
End page 92
Publisher Nature Publishing Group
Place of publication Adelaide, S. Aust.
Publication date 2007-02
ISSN 0818-9641
Keyword(s) chemokines
influenza A virus
T cells
Summary Influenza A viruses that circulate normally in the human population cause a debilitating, though generally transient, illness that is sometimes fatal, particularly in the elderly. Severe complications arising from pandemic influenza or the highly pathogenic avian H5N1 viruses are often associated with rapid, massive inflammatory cell infiltration, acute respiratory distress, reactive hemophagocytosis and multiple organ involvement. Histological and pathological indicators strongly suggest a key role for an excessive host response in mediating at least some of this pathology. Here, we review the current literature on how various effector arms of the immune system can act deleteriously to initiate or exacerbate pathological damage in this viral pneumonia. Generally, the same immunological factors mediating tissue damage during the anti-influenza immune response are also critical for efficient elimination of virus, thereby posing a significant challenge in the design of harmless yet effective therapeutic strategies for tackling influenza virus.
Language eng
DOI 10.1038/sj.icb.7100026
Field of Research 110804 Medical Virology
Socio Economic Objective 920108 Immune System and Allergy
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2007 Australasian Society for Immunology Inc. All rights reserved
Persistent URL http://hdl.handle.net/10536/DRO/DU:30028855

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 334 times in TR Web of Science
Scopus Citation Count Cited 341 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 868 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 26 May 2010, 16:06:26 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.