HIV vaccine rationale, design and testing

Slobod, Karen S., Coleclough, Chris, Bonsignori, Mattia, Brown, Scott A., Zhan, Xiaoyan, Surman, Sherri, Zirkel, Amy, Jones, Bart G., Sealy, Robert E., Stambas, John, Brown, Brita, Lockey, Timothy D., Freiden, Pamela J., Doherty, Peter C., Blanchard, James L., Martin, Louis N. and Hurwitz, Julia L. 2005, HIV vaccine rationale, design and testing, Current HIV research, vol. 3, no. 2, pp. 107-112, doi: 10.2174/1570162053506928.

Attached Files
Name Description MIMEType Size Downloads

Title HIV vaccine rationale, design and testing
Author(s) Slobod, Karen S.
Coleclough, Chris
Bonsignori, Mattia
Brown, Scott A.
Zhan, Xiaoyan
Surman, Sherri
Zirkel, Amy
Jones, Bart G.
Sealy, Robert E.
Stambas, JohnORCID iD for Stambas, John
Brown, Brita
Lockey, Timothy D.
Freiden, Pamela J.
Doherty, Peter C.
Blanchard, James L.
Martin, Louis N.
Hurwitz, Julia L.
Journal name Current HIV research
Volume number 3
Issue number 2
Start page 107
End page 112
Publisher Bentham Science Publishers Ltd.
Place of publication The Netherlands
Publication date 2005-04
ISSN 1570-162X
Keyword(s) HIV envelope protein
Summary A central obstacle to the design of a global HIV vaccine is viral diversity. Antigenic differences in envelope proteins result in distinct HIV serotypes, operationally defined such that antibodies raised against envelope molecules from one serotype will not bind envelope molecules from a different serotype. The existence of serotypes has presented a similar challenge to vaccine development against other pathogens. In such cases, antigenic diversity has been addressed by vaccine design. For example, the poliovirus vaccine includes three serotypes of poliovirus, and Pneumovax® presents a cocktail of 23 pneumococcal variants to the immune system. It is likely that a successful vaccine for HIV must also comprise a cocktail of antigens. Here, data relevant to the development of cocktail vaccines, designed to harness diverse, envelope-specific Bcell and T-cell responses, are reviewed.
Language eng
DOI 10.2174/1570162053506928
Field of Research 110804 Medical Virology
Socio Economic Objective 920109 Infectious Diseases
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice © 2005 Bentham Science Publishers Ltd.
Persistent URL

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Connect to link resolver
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 13 times in TR Web of Science
Scopus Citation Count Cited 14 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 920 Abstract Views, 0 File Downloads  -  Detailed Statistics
Created: Wed, 26 May 2010, 16:07:14 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact