A novel approach identified the FOLR1 gene, a putative regulator of milk protein synthesis

Menzies, Karensa K., Lefevre, Christophe, Sharp, Julie A., Macmillan, Keith L., Sheehy, Paul A. and Nicholas, Kevin R. 2009, A novel approach identified the FOLR1 gene, a putative regulator of milk protein synthesis, Mammalian genome, vol. 20, no. 8, pp. 498-503, doi: 10.1007/s00335-009-9207-4.

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Title A novel approach identified the FOLR1 gene, a putative regulator of milk protein synthesis
Formatted title A novel approach identified the FOLR1 gene, a putative regulator of milk protein synthesis

Author(s) Menzies, Karensa K.
Lefevre, Christophe
Sharp, Julie A.ORCID iD for Sharp, Julie A. orcid.org/0000-0002-4481-5223
Macmillan, Keith L.
Sheehy, Paul A.
Nicholas, Kevin R.
Journal name Mammalian genome
Volume number 20
Issue number 8
Start page 498
End page 503
Total pages 6
Publisher Springer New York
Place of publication New York, N. Y.
Publication date 2009
ISSN 0938-8990
Keyword(s) Artocephalus pusillus pusillus
Mactropus eugenii
Bos taurus
milk protein synthesis
mammary gene expression
microarray analysis
Summary This study has utilised comparative functional genomics to exploit animal models with extreme adaptation to lactation to identify candidate genes that specifically regulate protein synthesis in the cow mammary gland. Increasing milk protein production is valuable to the dairy industry. The lactation strategies of both the Cape fur seal (Artocephalus pusillus pusillus) and the tammar wallaby (Macropus eugenii) include periods of high rates of milk protein synthesis during an established lactation and therefore offer unique models to target genes that specifically regulate milk protein synthesis. Global changes in mammary gene expression in the Cape fur seal, tammar wallaby, and the cow (Bos taurus) were assessed using microarray analysis. The folate receptor α (FOLR1) showed the greatest change in gene expression in all three species [cow 12.7-fold (n = 3), fur seal 15.4-fold (n = 1), tammar 2.4-fold (n = 4)] at periods of increased milk protein production. This compliments previous reports that folate is important for milk protein synthesis and suggests FOLR1 may be a key regulatory point of folate metabolism for milk protein synthesis within mammary epithelial cells (lactocytes). These data may have important implications for the dairy industry to develop strategies to increase milk protein production in cows. This study illustrates the potential of comparative genomics to target genes of interest to the scientific community.
Language eng
DOI 10.1007/s00335-009-9207-4
Field of Research 060405 Gene Expression (incl Microarray and other genome-wide approaches)
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
HERDC collection year 2009
Copyright notice ©2009, Springer
Persistent URL http://hdl.handle.net/10536/DRO/DU:30029288

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