Docosapentaenoic acid (22:5n-3) : a review of its biological effects Kaur, Gunveen, Cameron-Smith, David, Garg, Manohar and Sinclair, Andrew J. 2011, Docosapentaenoic acid (22:5n-3) : a review of its biological effects, Progress in lipid research, vol. 50, no. 1, pp. 28-34, doi: 10.1016/j.plipres.2010.07.004. Attached Files Name Description MIMEType Size Downloads Title Docosapentaenoic acid (22:5n-3) : a review of its biological effects Author(s) Kaur, Gunveen orcid.org/0000-0002-6250-0495 Cameron-Smith, David Garg, Manohar Sinclair, Andrew J. Journal name Progress in lipid research Volume number 50 Issue number 1 Start page 28 End page 34 Total pages 7 Publisher Elsevier Place of publication Amsterdam, The Netherlands Publication date 2011-01 ISSN 0163-7827 1873-2194 Keyword(s) n-3 Polyunsaturated fatty acids (VLCPUFA) eicosapentaenoic acid (EPA) docosapentaenoic acid (DPA) docosahexaenoic acid (DHA) Summary This article summarizes the current knowledge available on metabolism and the biological effects of n-3 docosapentaenoic acid (DPA). n-3 DPA has not been extensively studied because of the limited availability of the pure compound. n-3 DPA is an elongated metabolite of EPA and is an intermediary product between EPA and DHA. The literature on n-3 DPA is limited, however the available data suggests it has beneficial health effects. In vitro n-3 DPA is retro-converted back to EPA, however it does not appear to be readily metabolised to DHA. In vivo studies have shown limited conversion of n-3 DPA to DHA, mainly in liver, but in addition retro-conversion to EPA is evident in a number of tissues. n-3 DPA can be metabolised by lipoxygenase, in platelets, to form ll-hydroxy-7,9,13,16,19- and 14-hydroxy-7,10,12,16,19-DPA. It has also been reported that n-3 DPA is effective (more so than EPA and DHA) in inhibition of aggregation in platelets obtained from rabbit blood. In addition, there is evidence that n-3 DPA possesses 10-fold greater endothelial cell migration ability than EPA, which is important in wound-healing processes. An in vivo study has reported that n-3 DPA reduces the fatty acid synthase and malic enzyme activity levels in n-3 DPA-supplemented mice and these effects were stronger than the EPA-supplemented mice. Another recent in vivo study has reported that n-3 DPA may have a role in attenuating age-related decrease in spatial learning and long-term potentiation. However, more research remains to be done to further investigate the biological effects of this n-3 VLCPUFA. Language eng DOI 10.1016/j.plipres.2010.07.004 Field of Research 110101 Medical Biochemistry: Amino Acids and Metabolites Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2010, Elsevier Ltd. Persistent URL http://hdl.handle.net/10536/DRO/DU:30029845 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 27 Aug 2010, 11:47:26 EST Fri, 27 Aug 2010, 11:49:47 EST Fri, 08 Oct 2010, 14:14:16 EST Thu, 14 Apr 2011, 14:39:43 EST Thu, 14 Apr 2011, 14:40:40 EST Mon, 17 Jun 2013, 16:29:03 EST Tue, 25 Jun 2013, 16:28:11 EST Mon, 16 Jun 2014, 16:14:18 EST Mon, 19 Jan 2015, 11:11:10 EST Tue, 27 Jan 2015, 09:48:56 EST Filtered Full Citation counts:   Cited 219 times in TR Web of Science Cited 228 times in Scopus Search Google Scholar Access Statistics: 1167 Abstract Views, 4 File Downloads  -  Detailed Statistics Created: Fri, 27 Aug 2010, 11:47:16 EST by Leanne Swaneveld