Sodium appetite in adult rats following ω-3 polyunsaturated fatty acid deficiency in early development Weisinger, R. S., Armitage, J. A., Chen, N., Begg, D. P., Mathai, M. L., Jayasooriya, A. P., Sinclair, A. J. and Weisinger, H. S. 2010, Sodium appetite in adult rats following ω-3 polyunsaturated fatty acid deficiency in early development, Appetite, vol. 55, no. 3, pp. 393-397, doi: 10.1016/j.appet.2010.07.006. Attached Files Name Description MIMEType Size Downloads Title Sodium appetite in adult rats following ω-3 polyunsaturated fatty acid deficiency in early development Author(s) Weisinger, R. S. Armitage, J. A. Chen, N. Begg, D. P. Mathai, M. L. Jayasooriya, A. P. Sinclair, A. J. Weisinger, H. S. orcid.org/0000-0001-6044-3653 Journal name Appetite Volume number 55 Issue number 3 Start page 393 End page 397 Total pages 5 Publisher Elsevier BV Place of publication Dordrecht, The Netherlands Publication date 2010-12 ISSN 0195-6663 1095-8304 Keyword(s) salt appetite ω-3 fatty acid deficiency fos fluid intake sodium balance Summary We examined the effect of ω-3 polyunsaturated fatty acid (PUFA) deficiency during development on sodium appetite. Being raised on an ω-3 PUFA deficient diet increased the intake of 0.5 M NaCl following furosemide-induced sodium depletion by 40%. This occurred regardless of the diet they were maintained on later in life, and the increased consumption persisted for 3 days. In a second study, animals were administered furosemide and low-dose captopril. Sodium consumption of deficient raised animals was again higher than that of the control raised. Fos immunoreactivity in brain areas associated with sodium appetite and excretion were not influenced by diet. Our findings indicate that inadequate dietary ω-3 PUFA during development results in an exaggerated sodium appetite later in life. Language eng DOI 10.1016/j.appet.2010.07.006 Field of Research 110101 Medical Biochemistry: Amino Acids and Metabolites Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2010, Elsevier Ltd. Persistent URL http://hdl.handle.net/10536/DRO/DU:30029853 Document type: Journal Article Collections: Faculty of Health School of Medicine Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 27 Aug 2010, 13:52:20 EST Fri, 27 Aug 2010, 13:53:27 EST Fri, 27 Aug 2010, 13:54:31 EST Fri, 08 Oct 2010, 14:18:39 EST Wed, 27 Apr 2011, 10:37:47 EST Fri, 10 Jun 2011, 15:27:07 EST Thu, 15 May 2014, 09:59:32 EST Mon, 16 Jun 2014, 16:14:32 EST Filtered Full Citation counts:   Cited 8 times in TR Web of Science Cited 8 times in Scopus Search Google Scholar Access Statistics: 936 Abstract Views, 1 File Downloads  -  Detailed Statistics Created: Fri, 27 Aug 2010, 13:52:11 EST by Leanne Swaneveld