Preliminary results of the application of a silk fibroin scaffold to otology Levin, Brett, Redmond, Sharon Leanne, Rajkhowa, Rangam, Eikelboom, Robert Henry, Marano, Robert Jeffery and Atlas, Marcus David 2010, Preliminary results of the application of a silk fibroin scaffold to otology, Otolaryngology–head and neck surgery, vol. 142, no. 3, Supplement 1, pp. S33-S35, doi: 10.1016/j.otohns.2009.06.746. Attached Files Name Description MIMEType Size Downloads Title Preliminary results of the application of a silk fibroin scaffold to otology Author(s) Levin, Brett Redmond, Sharon Leanne Rajkhowa, Rangam orcid.org/0000-0002-6811-9126 Eikelboom, Robert Henry Marano, Robert Jeffery Atlas, Marcus David Journal name Otolaryngology–head and neck surgery Volume number 142 Issue number 3 Season Supplement 1 Start page S33 End page S35 Total pages 3 Publisher Mosby, Inc. Place of publication Philadelphia, Pa. Publication date 2010-03 ISSN 0194-5998 1097-6817 Summary The surgical treatment to repair chronic tympanic membrane perforations is myringoplasty. Although multiple autologous grafts, allografts, and synthetic graft materials have been used over the years, no single graft material is superior for repairing all perforation types. Recently, the remarkable properties of silk fibroin protein have been studied, with biomedical and tissue engineering applications in mind, across a number of medical and surgical disciplines. The present study examines the use of silk fibroin for its potential suitability as an alternative graft in myringoplasty surgery by investigating the growth and proliferation of human tympanic membrane keratinocytes on a silk fibroin scaffold in vitro. Light microscopy, immunofluorescent staining, and confocal imaging all reveal promising preliminary results. The biocompatibility, transparency, stability, high tensile strength, and biodegradability of fibroin make this biomaterial an attractive option to study for this utility. Language eng DOI 10.1016/j.otohns.2009.06.746 Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified Socio Economic Objective 920107 Hearing, Vision, Speech and Their Disorders HERDC Research category C1 Refereed article in a scholarly journal HERDC collection year 2010 Copyright notice ©2010, American Academy of Otolaryngology–Head and Neck Surgery Foundation. All rights reserved. Persistent URL http://hdl.handle.net/10536/DRO/DU:30031148 Document type: Journal Article Collections: Centre for Material and Fibre Innovation Institute for Technology Research and Innovation GTP Research Related Links Link Description Connect to published version (restricted access) Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Versions Version Filter Type Fri, 12 Nov 2010, 14:43:20 EST Fri, 12 Nov 2010, 14:44:40 EST Mon, 15 Nov 2010, 15:22:25 EST Tue, 16 Nov 2010, 08:50:04 EST Tue, 16 Nov 2010, 08:50:49 EST Tue, 16 Nov 2010, 08:51:48 EST Tue, 16 Nov 2010, 08:55:08 EST Mon, 17 Jan 2011, 16:15:36 EST Tue, 18 Jan 2011, 11:57:41 EST Tue, 18 Jan 2011, 11:58:52 EST Mon, 16 Jun 2014, 16:48:06 EST Fri, 22 Aug 2014, 14:54:04 EST Filtered Full Citation counts:   Cited 22 times in TR Web of Science Cited 24 times in Scopus Search Google Scholar Access Statistics: 900 Abstract Views, 6 File Downloads  -  Detailed Statistics Created: Fri, 12 Nov 2010, 14:43:20 EST by Christine Rimmer