New insights into protein export in malaria parasites

Haase, Silvia and de Koning-Ward, Tania F. 2010, New insights into protein export in malaria parasites, Cellular microbiology, vol. 12, no. 5, pp. 580-587, doi: 10.1111/j.1462-5822.2010.01455.x.

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Title New insights into protein export in malaria parasites
Author(s) Haase, Silvia
de Koning-Ward, Tania F.ORCID iD for de Koning-Ward, Tania F.
Journal name Cellular microbiology
Volume number 12
Issue number 5
Start page 580
End page 587
Total pages 8
Publisher Wiley-Blackwell Publishing
Place of publication London, England
Publication date 2010-05
ISSN 1462-5814
Keyword(s) malaria
Summary In order to survive and promote its virulence the malaria parasite must export hundreds of its proteins beyond an encasing vacuole and membrane into the host red blood cell. In the last few years, several major advances have been made that have significantly contributed to our understanding of this export process. These include: (i) the identification of sequences that direct protein export (a signal sequence and a motif termed PEXEL), which have allowed predictions of the exportomes of Plasmodium species that are the cause of malaria, (ii) the recognition that the fate of proteins destined for export is already decided within the parasite's endoplasmic reticulum and involves the PEXEL motif being recognized and cleaved by the aspartic protease plasmepsin V and (iii) the discovery of the Plasmodium translocon of exported proteins (PTEX) that is responsible for the passage of proteins across the vacuolar membrane. We review protein export in Plasmodium and these latest developments in the field that have now provided a new platform from which trafficking of malaria proteins can be dissected.
Language eng
DOI 10.1111/j.1462-5822.2010.01455.x
Field of Research 060108 Protein Trafficking
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Blackwell Publishing
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