Protein export in Plasmodium parasites : from the endoplasmic reticulum to the vacuolar export machine

Crabb, Brendan S., de Koning-Ward, Tania F. and Gilson, Paul R. 2010, Protein export in Plasmodium parasites : from the endoplasmic reticulum to the vacuolar export machine, International Journal for parasitology, vol. 40, no. 5, pp. 509-513, doi: 10.1016/j.ijpara.2010.02.002.

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Title Protein export in Plasmodium parasites : from the endoplasmic reticulum to the vacuolar export machine
Author(s) Crabb, Brendan S.
de Koning-Ward, Tania F.ORCID iD for de Koning-Ward, Tania F.
Gilson, Paul R.
Journal name International Journal for parasitology
Volume number 40
Issue number 5
Start page 509
End page 513
Total pages 5
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2010-04
ISSN 0020-7519
Summary It is somewhat paradoxical that the malaria parasite’s survival strategy involves spending almost all of its blood-stage existence residing behind a two-membrane barrier in a host red blood cell, yet giving considerable attention to exporting parasite-encoded proteins back across these membranes. These exported proteins are thought to play diverse roles and are crucial in pathogenic processes, such as re-modelling of the erythrocyte cytoskeleton and mediating the export of a major virulence protein known as Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1), and in metabolic processes such as nutrient uptake and solute exchange. Despite these varied roles most exported proteins have at least one common link; they share a trafficking pathway that begins with entry into the endoplasmic reticulum and concludes with passage across the vacuole membrane via a proteinaceous translocon known as the Plasmodium translocon of exported proteins (PTEX). In this commentary we review recent advances in our understanding of this export pathway and suggest several models by which different aspects of the process may be interconnected.
Language eng
DOI 10.1016/j.ijpara.2010.02.002
Field of Research 110707 Innate Immunity
Socio Economic Objective 970106 Expanding Knowledge in the Biological Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2010, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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