CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle Papazzo, Annateresa, Lexis, Louise and Lewandowski, Paul 2010, CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle, Nutrition and Dietary Supplements, vol. 2, pp. 51-58, doi: 10.2147/NDS.S10955. Attached Files Name Description MIMEType Size Downloads lewandowski-coq10conveysprotection-2010.pdf Published version application/pdf 178.42KB 315 Title CoQ10 conveys protection from oxidative stress in plasma but not skeletal muscle Author(s) Papazzo, Annateresa Lexis, Louise Lewandowski, Paul Journal name Nutrition and Dietary Supplements Volume number 2 Start page 51 End page 58 Total pages 8 Publisher Dove Medical Press Ltd Place of publication Auckland, N.Z. Publication date 2010-07 ISSN 1179-1489 Keyword(s) coenzyme Q10 aging skeletal muscle oxidative damage gene expression Summary Coenzyme Q10 (CoQ10) is commonly consumed as an antiaging supplement at doses of 30–210 mg/day. The aim of the study was to determine if CoQ10 alters markers of antioxidant status, oxidative damage, and gene expression in aging skeletal muscle. Female guinea pigs aged 26 months were supplemented for 6 weeks with CoQ10 at a human equivalent dose of 10 mg/kg/day. Body weight, plasma CoQ10 concentration, and WBC DNA abasic sites were measured at weeks 0, 2, 4, and 6 of the supplementation period. At the end of supplementation, concentrations of skeletal muscle CoQ10, glutathione, malondialdehyde, protein carbonyls, DNA abasic sites, activities of catalase and glutathione peroxidase, and the gene expression of cyctochrome c oxidase subunits were measured. Dietary supplementation with CoQ10 elevated plasma CoQ10 levels (pre 73 ± 3 nmol/L, post 581 ± 15 nmol/L, P < 0.05) and decreased abasic sites in WBC DNA (pre 16.8 ± 0.5 Ap/100000 bp, post 9.7 ± 0.4 Ap/100000 bp, P < 0.05). In contrast, all of the measures made in skeletal muscle were not different between groups (P > 0.05). These results indicate that dietary supplementation with CoQ10 at a dose of 10 mg/kg/day may be capable of increasing antioxidant protection and reducing oxidative damage in the plasma, but may have no effect in skeletal muscle. Language eng DOI 10.2147/NDS.S10955 Field of Research 111103 Nutritional Physiology Socio Economic Objective 920411 Nutrition HERDC Research category C1 Refereed article in a scholarly journal Copyright notice ©2010, Papazzo et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. Free to Read? Yes Persistent URL http://hdl.handle.net/10536/DRO/DU:30031497 Document type: Journal Article Collections: Faculty of Health School of Medicine Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Thu, 09 Dec 2010, 08:45:57 EST Wed, 15 Dec 2010, 10:28:32 EST Wed, 15 Dec 2010, 10:31:09 EST Thu, 16 Dec 2010, 08:10:40 EST Thu, 16 Dec 2010, 08:11:50 EST Thu, 16 Dec 2010, 08:20:58 EST Thu, 20 Jan 2011, 11:35:35 EST Fri, 17 Oct 2014, 10:33:54 EST Tue, 06 Sep 2016, 16:11:04 EST Tue, 05 Dec 2017, 10:45:09 EST Fri, 07 Sep 2018, 15:11:24 EST Filtered Full Citation counts:   Cited 0 times in TR Web of Science Cited 0 times in Scopus Search Google Scholar Access Statistics: 1135 Abstract Views, 315 File Downloads  -  Detailed Statistics Created: Thu, 09 Dec 2010, 08:45:54 EST by Jane Moschetti