MicroRNA in human cancer and chronic inflammatory diseases

Kanwar, Jagat R., Mahidhara, Ganesh and Kanwar, Rupinder K. 2010, MicroRNA in human cancer and chronic inflammatory diseases, Frontiers in bioscience (scholar edition), vol. 2, pp. 1113-1126.

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Title MicroRNA in human cancer and chronic inflammatory diseases
Author(s) Kanwar, Jagat R.ORCID iD for Kanwar, Jagat R. orcid.org/0000-0003-3728-9568
Mahidhara, Ganesh
Kanwar, Rupinder K.
Journal name Frontiers in bioscience (scholar edition)
Volume number 2
Start page 1113
End page 1126
Total pages 14
Publisher Frontiers in Bioscience
Place of publication Albertson, N.Y.
Publication date 2010-06-01
ISSN 1093-9946
Summary MicroRNAs (miRNAs) are the non-coding RNAs that act as post-translational regulators to their complimentary messenger RNAs (mRNA). Due to their specific gene silencing property, miRNAs have been implicated in a number of cellular and developmental processes. Also, it has been proposed that a particular set of miRNA spectrum is expressed only in a particular type of tissue. Many interesting findings related to the differential expression of miRNAs in various human diseases including several types of cancers, neurodegenerative diseases and metabolic diseases have been reported. Deregulation of miRNA expression in different types of human diseases and the roles various miRNAs play as tumour suppressors as well as oncogenes, suggest their contribution to cancer and/or in other disease development. These findings have possible implications in the development of diagnostics and/or therapeutics in human malignancies. In this review, we discuss various miRNAs that are differentially expressed in human chronic inflammatory diseases, neurodegenerative diseases, cancer and the further prospective development of miRNA based diagnostics and therapeutics.
Language eng
Field of Research 060199 Biochemistry and Cell Biology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Persistent URL http://hdl.handle.net/10536/DRO/DU:30031523

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