Developmental outcomes of children exposed to antidepressants in pregnancy

Galbally, Megan, Lewis, Andrew J. and Buist, Anne 2011, Developmental outcomes of children exposed to antidepressants in pregnancy, Australian & New Zealand journal of psychiatry, vol. 45, no. 5, pp. 393-399, doi: 10.3109/00048674.2010.549995.

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Title Developmental outcomes of children exposed to antidepressants in pregnancy
Author(s) Galbally, Megan
Lewis, Andrew J.ORCID iD for Lewis, Andrew J.
Buist, Anne
Journal name Australian & New Zealand journal of psychiatry
Volume number 45
Issue number 5
Start page 393
End page 399
Total pages 6
Publisher Informa Healthcare
Place of publication London, England
Publication date 2011-05
ISSN 0004-8674
Keyword(s) antidepressants
child development
Summary Objective: To examine the developmental outcomes in children exposed to antidepressants in utero and compare those to children not exposed to these medications
Method: A prospective case-controlled study of children exposed to antidepressants in pregnancy assessed 22 exposed and 19 not exposed children using the Bayley Scales of Infant Development, third edition. The control group was measured at a mean age of 23.09 (SD 3.82) months and the medicated group at 28.53 months (SD 6.22). Maternal variables were assessed using a purpose-designed questionnaire and the Beck Depression Inventory (II) in pregnancy and at three assessments in the postpartum.
Results: Children exposed to antidepressant medication in pregnancy scored lower on motor subscales in particular on fine motor scores than non-exposed children with a moderate effect size of Cohen ’ s d = 0.47 fi ne motor and Cohen ’ s d = 0.43 for gross motor. Due to lack of power these findings did not reach conventional criteria for statistical significance. There was no association found between maternal depression and neurodevelopment.
Conclusions: This finding of a possible effect from antidepressant exposure in pregnancy on children ’ s motor development is similar to the findings from a previous study. Future research is needed which assesses children at an older age using specific assessments of motor development.
Notes Posted online on 11 Feb 2011
Language eng
DOI 10.3109/00048674.2010.549995
Field of Research 170102 Developmental Psychology and Ageing
Socio Economic Objective 970117 Expanding Knowledge in Psychology and Cognitive Sciences
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2011, The Royal Australian and New Zealand College of Psychiatrists
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Created: Wed, 16 Feb 2011, 10:34:45 EST by Jane Moschetti

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