Association between magnesium intake and depression and anxiety in community-dwelling adults : The Hordaland Health Study

Jacka, Felice N., Overland, Simon, Stewart, Robert, Tell, Grethe S., Bjelland, Ingvar and Mykletun, Arnstein 2009, Association between magnesium intake and depression and anxiety in community-dwelling adults : The Hordaland Health Study, Australian & New Zealand journal of psychiatry, vol. 43, no. 1, pp. 45-52, doi: 10.1080/00048670802534408.

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Title Association between magnesium intake and depression and anxiety in community-dwelling adults : The Hordaland Health Study
Author(s) Jacka, Felice N.ORCID iD for Jacka, Felice N.
Overland, Simon
Stewart, Robert
Tell, Grethe S.
Bjelland, Ingvar
Mykletun, Arnstein
Journal name Australian & New Zealand journal of psychiatry
Volume number 43
Issue number 1
Start page 45
End page 52
Total pages 8
Publisher Informa Healthcare
Place of publication Melbourne, Vic.
Publication date 2009-01
ISSN 0004-8674
Keyword(s) anxiety
Summary Objective: Systemic inflammation is associated with both the dietary intake of magnesium, and depression. Limited experimental and clinical data suggest an association between magnesium and depression. Thus, there are reasons to consider dietary magnesium as a variable of interest in depressive disorders. The aim of the present study was to examine the association between magnesium intake and depression and anxiety in a large sample of community-dwelling men and women. This sample consisted of 5708 individuals aged 46–49 or 70–74 years who participated in the Hordaland Health Study in Western Norway.

Methods: Symptoms of depression and anxiety were self-reported using the Hospital Anxiety and Depression Scale, and magnesium intake was assessed using a comprehensive food frequency questionnaire.

Results: There was an inverse association between standardized energy-adjusted magnesium intake and standardized depression scores that was not confounded by age, gender, body habitus or blood pressure (β=−0.16, 95% confidence interval (CI)=−0.22 to −0.11). The association was attenuated after adjustment for socioeconomic and lifestyle variables, but remained statistically significant (β=−0.11, 95%CI=−0.16 to −0.05). Standardized magnesium intake was also related to case-level depression (odds ratio (OR)=0.70, 95%CI=0.56–0.88), although the association was attenuated when adjusted for socioeconomic and lifestyle factors (OR=0.86, 95%CI=0.69–1.08). The inverse relationship between magnesium intake and score and case-level anxiety was weaker and not statistically significant in the fully adjusted models.

The hypothesis that magnesium intake is related to depression in the community is supported by the present findings. These findings may have public health and treatment implications.
Language eng
DOI 10.1080/00048670802534408
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2009, The Royal Australian and New Zealand College of Psychiatrists
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