Annual high-dose vitamin D3 and mental well-being: randomised controlled trial

Sanders, Kerrie M., Stuart, Amanda L., Wiliamson, Elizabeth J., Jacka, Felice N., Dodd, Seetal, Nicholson, Geoff and Berk, Michael 2011, Annual high-dose vitamin D3 and mental well-being: randomised controlled trial, British journal of psychiatry, vol. 198, no. 5, pp. 357-364.

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Title Annual high-dose vitamin D3 and mental well-being: randomised controlled trial
Author(s) Sanders, Kerrie M.
Stuart, Amanda L.ORCID iD for Stuart, Amanda L.
Wiliamson, Elizabeth J.
Jacka, Felice N.ORCID iD for Jacka, Felice N.
Dodd, SeetalORCID iD for Dodd, Seetal
Nicholson, Geoff
Berk, MichaelORCID iD for Berk, Michael
Journal name British journal of psychiatry
Volume number 198
Issue number 5
Start page 357
End page 364
Total pages 8
Publisher Royal College of Psychiatrists
Place of publication London, England
Publication date 2011-05
ISSN 0007-1250
Keyword(s) mental health
Summary Background Epidemiological evidence supports a relationship between vitamin D and mental well-being, although evidence from large-scale placebo-controlled intervention trials is lacking.

Aims To examine if vitamin D supplementation has a beneficial effect on mood in community-dwelling older women; if a single annual large dose of vitamin D has a role in the prevention of depressive symptoms; and if there is an association between serum 25-hydroxyvitamin D levels and mental health.

Method A double-blind, randomised, placebo-controlled trial of women aged 70 or older (the Vital D Study: ISRCTN83409867 and ACTR12605000658617). Participants were randomly assigned to receive 500 000 IU vitamin D3 (cholecalciferol) orally or placebo every autumn/winter for 3–5 consecutive years. The tools utilised at various time points were the General Health Questionnaire, the 12-item Short Form Health Survey, the Patient Global Impression–Improvement scale and the WHO Well-Being Index. Serum 25-hydroxyvitamin D levels were measured in a subset of 102 participants.

Results In this non-clinical population, no significant differences between the vitamin D and placebo groups were detected in any of the measured outcomes of mental health. Serum 25-hydroxyvitamin D levels in the vitamin D group were 41% higher than the placebo group 12 months following their annual dose. Despite this difference, scores from the questionnaires did not differ. Furthermore, there was no interaction between those on antidepressant/anxiety medication at baseline and the treatment groups.

Conclusions The lack of improvement in indices of mental well-being in the vitamin D group does not support the hypothesis that an annual high dose of vitamin D3 is a practical intervention to prevent depressive symptoms in older community-dwelling women.
Language eng
Field of Research 119999 Medical and Health Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Royal College of Psychiatrists
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